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Effect of metallization on porphyrin photoacoustic response

2019; Elsevier BV; Volume: 738; Linguagem: Inglês

10.1016/j.cplett.2019.136875

1873-4448

André Miele Amado, João Henrique Uliana, Theo Z. Pavan, Iouri E. Borissevitch,

Photodynamic Therapy Research Studies

Photoacoustic imaging (PAI) has been evaluated to visualize small neoplastic lesions inside normal tissues. PAI is based on the detection of pressure waves generated due to the absorption of light energy by a photosensitizer (PS) within the tissue. Porphyrins possess high affinity to tumor tissue thus can be considered as an appropriate PS. PS complexation with metals can increase the heat production at the PS excitation; therefore, increasing the PA response. We have demonstrated the increase of the TPPS4 and TMPyP porphyrin PA response at their complexation with Fe3+,Mn3+,Cu2+ and Zn2+ metal ions in aqueous solutions.