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Interstitial lung abnormalities in patients with early rheumatoid arthritis: A pilot study evaluating prevalence and progression

2019; AVES Yayincilik; Volume: 6; Issue: 4 Linguagem: Inglês

10.5152/eurjrheum.2019.19044

2147-9720

Huawei Dong, Peter Julien, M. Kristen Demoruelle, Kevin D. Deane, Michael H. Weisman,

Sarcoidosis and Beryllium Toxicity Research

Interstitial lung abnormalities in patients with early rheumatoid arthritis: A pilot study evaluating prevalence and progressionOn high-resolution computerized tomography (HRCT), RA-associated ILD can present as multiple radiographic patterns, including usual interstitial pneumonia (UIP) characterized by fibrosis and honeycombing, as well as non-specific interstitial pneumonia (NSIP) distinguished by extensive ground glass opacities (4-5).Imaging features of reticular thickening, honeycombing, traction bronchiectasis, and/or ground glass opacities, without a diagnosis of UIP or NSIP, have been termed interstitial lung abnormalities (ILA), and they are thought to represent subclinical disease (6).Multiple cross-sectional studies using HRCT have identified a high prevalence of ILAs in patients with early RA (7-14).However, the time course and significance of subtle findings of ILAs, often in the absence of significant respiratory symptoms, are not known.In addition, there is limited knowledge about the factors that may be associated with the prevalence and progression of ILAs in RA.