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Evolution of Myeloma Testing in Clinical Chemistry with Mass Spectrometry

2019; Oxford University Press; Volume: 4; Issue: 3 Linguagem: Inglês

10.1373/jalm.2018.028902

2576-9456

David Murray, Maria Alice V. Willrich,

HIV/AIDS drug development and treatment

Dramatic improvement in the treatment response of multiple myeloma (MM)2 patients to new chemotherapy and immunotherapy has sparked a reevaluation of long-held assumptions about this disease. In the forefront is the hope that MM may be curable, and perhaps it is time to start treating MM patients until all signs of the disease are eradicated. For those of us in the clinical laboratory, this poses a challenge to provide more sensitive assays capable of detecting minimal residual disease. The long-standing routine electrophoretic methods are not capable of providing the needed sensitivity, and laboratorians have turned to bone marrow biopsies and hunting for traces of the malignant plasma cells with high-sensitivity flow cytometry and next-generation sequencing. At our institution, agarose gel electrophoresis has been used for detecting MM since 1967. Since that time, the assay has seen relatively …