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Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant

2019; Massachusetts Medical Society; Volume: 381; Issue: 21 Linguagem: Inglês

10.1056/nejmoa1910437

1533-4406

Zachariah DeFilipp, Patricia P. Bloom, Mariam Torres Soto, Michael K. Mansour, Mohamad Sater, Miriam Huntley, Sarah E. Turbett, Raymond T. Chung, Yi‐Bin Chen, Elizabeth Hohmann,

Helicobacter pylori-related gastroenterology studies

Fecal microbiota transplantation (FMT) is an emerging therapy for recurrent or refractory Clostridioides difficile infection and is being actively investigated for other conditions. We describe two patients in whom extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli bacteremia occurred after they had undergone FMT in two independent clinical trials; both cases were linked to the same stool donor by means of genomic sequencing. One of the patients died. Enhanced donor screening to limit the transmission of microorganisms that could lead to adverse infectious events and continued vigilance to define the benefits and risks of FMT across different patient populations are warranted.