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Human cytomegalovirus-encoded MicroRNAs: A master regulator of latent infection

2019; Elsevier BV; Volume: 78; Linguagem: Inglês

10.1016/j.meegid.2019.104119

1567-7257

Abualgasim Elgaili Abdalla, Mahjoob Osman Mahjoob, Khalid Omer Abdalla Abosalif, Hasan Ejaz, Ayman Ali Mohammed Alameen, Tilal Elsaman,

Extracellular vesicles in disease

Human cytomegalovirus (HCMV) can modulate the host cell microenvironment to cause latent infection and is therefore considered a major health concern in immunocompromised patients. HCMV-encoded microRNAs (miRs) have emerged as a key player in regulating the expression of the host cell and viral genes to induce latent infection. HCMV-encoded miRs can inhibit antiviral immune responses, such as proinflammatory mediators production, antigenic presentation, and apoptosis. In addition, HCMV miRs can reduce viral DNA replication. In this review, we describe the mechanisms underlying HCMV-encoded miR-mediated regulation of latent infection that may be exploited for future designing novel miRs-directed therapies.