Produção Nacional
Revisado por pares
Light-induced disruption of an acyl hydrazone link as a novel strategy for drug release and activation: isoniazid as a proof-of-concept case
2019; Royal Society of Chemistry; Volume: 7; Issue: 4 Linguagem: Inglês
10.1039/c9qi01172b
ISSN2052-1553
AutoresEdinaira Deodato Nunes, Anne Drumond Villela, Luiz Augusto Basso, Edson Holanda Teixeira, Alexandre Lopes Andrade, Mayron Alves de Vasconcelos, Luiz Gonzaga do Nascimento Neto, Ana C. S. Gondim, Izaura C.N. Diógenes, Adolfo I. B. Romo, Otaciro R. Nascimento, Dávila Zampieri, Tércio de F. Paulo, Idalina M.M. de Carvalho, Luiz Gonzaga de França Lopes, Eduardo H. S. Sousa,
Tópico(s)Catalytic C–H Functionalization Methods
ResumoPhotocleavage of an acyl hydrazone bridge was achieved by conjugating isoniazid to a ruthenium( ii ) metal complex through the generation of singlet oxygen, which released and activated the anti-tuberculosis pro-drug isoniazid.
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