Sessile serrated adenoma/polyp showed rapid malignant transformation in the final 13 months
2019; Wiley; Volume: 32; Issue: 6 Linguagem: Inglês
10.1111/den.13572
ISSN1443-1661
AutoresSadahiro Amemori, Hiro‐o Yamano, Yoshihito Tanaka, Kenjiro Yoshikawa, Hiro‐o Matsushita, Ryo Takagi, Eiji Harada, Yuko Yoshida, Kazunori Tsuda, Kato Bun'ichiro, Eri Tamura, Makoto Eizuka, Tamotsu Sugai, Yasushi Adachi, Eiichiro Yamamoto, Hiromu Suzuki, Hiroshi Nakase,
Tópico(s)Colorectal Cancer Treatments and Studies
ResumoBased on the concept of the adenoma‐carcinoma sequence, most colorectal cancers are considered to arise from conventional adenomas. However, recent studies suggested that a subset of colorectal cancers develop through the serrated neoplastic pathway. It has also been documented that serrated polyps can rapidly transform into invasive cancers even when they are small in size. We now describe a case of a sessile serrated adenoma/polyp which had been followed up for 4 years but eventually showed rapid transformation into an advanced cancer accompanied by a remarkable morphological change within only 13 months. Retrospective genetic and epigenetic analyses showed microsatellite instability, CpG island methylator phenotype‐positive, and BRAF mutation in the lesion, suggesting the tumor had developed through the serrated neoplastic pathway. This case may provide valuable information about the natural history of sessile serrated adenoma/polyps which eventually progress to advanced cancers.
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