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Antioxidant, hepatoprotective, genoprotective, and cytoprotective effects of quercetin in a murine model of arthritis

2019; Wiley; Volume: 121; Issue: 4 Linguagem: Inglês

10.1002/jcb.29502

1097-4644

Renata da Silva Pereira Saccol, Karine Lanes da Silveira, Alessandra G. Manzoni, Fátima Husein Abdalla, Juliana Sorraila de Oliveira, Guilherme Lopes Dornelles, Fernanda Barbisan, Daniela F. Passos, Émerson André Casali, Cínthia Melazzo de Andrade, Ivana Beatrice Mânica da Cruz, Daniela Bitencourt Rosa Leal,

Genomics, phytochemicals, and oxidative stress

Abstract Rheumatoid arthritis is a highly debilitating inflammatory autoimmune disease which is characterized by joint destruction. The present study sought to investigate the effect of quercetin in rats with complete Freund's adjuvant‐induced arthritis. Animals were divided into control/saline, control/quercetin (5 mg/kg, 25 mg/kg, and 50 mg/kg) arthritis/saline, and arthritis/quercetin (5 mg/kg, 25 mg/kg, and 50 mg/kg); the treatments were administered for 45 days. Biochemical, oxidative stress, genotoxicity, and cytotoxicity parameters were evaluated. All doses of quercetin reduced the levels of aspartate aminotransferase, thiobarbituric acid‐reactive substances, and reactive oxygen species; however, only treatment with 25 or 50 mg/kg increased catalase activity. Total thiol and reduced glutathione levels were not significantly affected by the induction nor by the treatments. Genotoxicity assessed by DNA damage, and cytotoxicity through picogreen assay, decreased after treatments with quercetin. Our results present evidence of the antioxidant, cytoprotective, genoprotective and hepatoprotective, and effects of quercetin, demonstrating its potential as a candidate for coadjuvant therapy.