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Zingiber officinale formulation reduces hepatic injury and weight gain in rats fed an unhealthy diet

2019; Brazilian Academy of Sciences; Volume: 91; Issue: 4 Linguagem: Inglês

10.1590/0001-3765201920180975

1678-2690

Dalila Teixeira Leal, Gleide Gatti Fontes, Julia Khéde Dourado Villa, Rodrigo Barros Freitas, Mateus Gandra Campos, Camilo Amaro de Carvalho, Virgínia Ramos Pizziolo, Marisa Alves Nogueira Diaz,

Drug-Induced Hepatotoxicity and Protection

This study investigated the ability of formulation containing Zingiber officinale (ginger) to reverse health changes promoted by unhealthy diet in Wistar rats. Five compounds from the gingerol family and three from the shogaol family were identified in the chromatographic analyzes of the extract. The animals were fed a combination of unhealthy foods, the cafeteria diet, which promoted increases in body weight, hepatocyte nucleus area, total hepatocyte area and liver fat accumulation, as well as reduced hepatic glutathione S-transferase concentration, compared to the control group, which received commercial chow. The treatment with ginger improved all these results, highlighting the reduction of 10% of body weight and 66% of the total area of lipid droplets deposited, compared to the group that received the cafeteria diet. Ginger treatments also attenuated lipid peroxidation, with a mean reduction of 41% in malondialdehyde levels and a mean increase of 222% in glutathione S-transferase activity in the liver. The cafeteria diet and ginger extract did not promote significant changes in glycemic and lipid profile, liver weight and liver enzymes compared to the control group. We suggest that ginger can have beneficial effects on health complications associated with unhealthy diet, such as excessive adiposity, oxidative stress and hepatic injury.