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Iron-Based Core–Shell Nanowires for Combinatorial Drug Delivery and Photothermal and Magnetic Therapy

2019; American Chemical Society; Volume: 11; Issue: 47 Linguagem: Inglês

10.1021/acsami.9b17512

1944-8252

Aldo Isaac Martínez-Banderas, Antonio Aires, Marta Quintanilla, Jorge A. Holguín‐Lerma, Claudia Lozano-Pedraza, Francisco J. Terán, Julián A. Moreno, Jose E. Perez, Boon S. Ooi, Timothy Ravasi, Jasmeen S. Merzaban, Aitziber L. Cortajarena, Jürgen Kosel,

Gold and Silver Nanoparticles Synthesis and Applications

Combining different therapies into a single nanomaterial platform is a promising approach for achieving more efficient, less invasive, and personalized treatments. Here, we report on the development of such a platform by utilizing nanowires with an iron core and iron oxide shell as drug carriers and exploiting their optical and magnetic properties. The iron core has a large magnetization, which provides the foundation for low-power magnetic manipulation and magnetomechanical treatment. The iron oxide shell enables functionalization with doxorubicin through a pH-sensitive linker, providing selective intracellular drug delivery. Combined, the core–shell nanostructure features an enhanced light–matter interaction in the near-infrared region, resulting in a high photothermal conversion efficiency of >80% for effective photothermal treatment. Applied to cancer cells, the collective effect of the three modalities results in an extremely efficient treatment with nearly complete cell death (∼90%). In combination with the possibility of guidance and detection, this platform provides powerful tools for the development of advanced treatments.