Portal de Periódicos da CAPES

T serotyping of group a streptococcus isolated from patients with pharyngitis or streptococcal toxic shock syndrome in Japan between 2005 and 2017

2019; Elsevier BV; Volume: 26; Issue: 2 Linguagem: Inglês

10.1016/j.jiac.2019.10.010

1437-7780

Tadayoshi Ikebe, Rumi Okuno, Yumi Uchitani, Yoshiko Kanda, Mari Sasaki, Kaoru Uchida, Kazuki Chiba, Takahiro Yamaguchi, Hitoshi Otsuka, Miyuki Suzuki, Hitomi Ohya, Haruo Watanabe, Makoto Ohnishi, Yo Morimoto, Keiko Ogawa, Takayuki Konno, Kaori Iwabuchi, Junji Seto, Toshinobu Hoshi, Yuki Kimura, Ryouko Kikuchi, Kazunari Yamamoto, Miki Nagata, Keiji Funatogawa, Akira Wakatsuki, Tomoe Sao, Hajime kurosawa, Kazunori Kishida, Kentaro Tomari, Yuko Matsumoto, Eiko Yuzawa, Fumiko Saka, Takaya Yamagami, Yukiko Shimoda Igawa, Takayuki Shiomoto, Yusuke Sato, Shuntaro Umeda, Shinichiro Shibata, Makiko Noda, Yukiko Kadokura, Chikara Nakagawa, Megumi Okada, Hirotoshi Iwasawa, Yumi Akiyama, Noriko Nakanishi, Ryutaro Murayama, Masaki Hiragakiuchi, Takako Yoshida, Kayoko Nakaoka, Sakura Iwashita, Yuko Kiguchi, Kouji Takeuchi, Jun Kawase, Hideaki kariya, Takahiro Hiratsuka, Hiroko Akita, Kazuki Sato, Youko Iwashita, Go Sato, Aya Shinohara, Yuki Abe, Tae Taniwaki, Midori Kimura, Masato Miyahira, Tetsuya Kakita,

Otolaryngology and Infectious Diseases

Streptococcus pyogenes (group A streptococcus; GAS) is an important gram-positive human pathogen capable of causing diseases ranging from mild superficial skin and pharyngeal infections to more severe invasive diseases, including streptococcal toxic shock syndrome (STSS). GAS produces a T protein, and T serotyping has considerable discriminatory power for epidemiological characterization of GAS. To clarify the relationship between STSS and pharyngitis in Japan, we examined the T serotypes of GAS strains isolated from clinical specimens of streptococcal infections (STSS, 951 isolates; pharyngitis, 16268 isolates) from 2005 to 2017. The most prevalent T serotype from pharyngitis isolates was T12, followed by T1, T4, and TB3264. The most prevalent T serotype from STSS isolates was T1, followed by TB3264. Trend of increase and decrease in the frequency of T1 or TB3264 isolation from pharyngitis was correlated with that of STSS patients. The increase of T1 or TB3264 strain-infection in pharyngitis patients may increase the probability of causing STSS, indicating that careful monitoring of GAS serotypes is essential for the prediction of rapid increase of STSS in time to develop effective management strategies.