Synthesis of novel coumarinyl-pyrido[2,3- d ]pyrimidine-2,4-diones using task-specific magnetic ionic liquid, [AcMIm]FeCl 4 as catalyst
2019; Taylor & Francis; Volume: 50; Issue: 1 Linguagem: Inglês
10.1080/00397911.2019.1686526
ISSN1532-2432
AutoresSrinivasa Rao Ambati, Jeevan Lal Patel, Satish Gudala, Komal Chandrakar, Santhosh Penta, S. P. Mahapatra, Subhash Banerjee,
Tópico(s)Synthesis and Biological Evaluation
ResumoAn acid-functionalized magnetic ionic liquid, 1-acyl-3-methylimidazolium tetrachloroferrate, [AcMIm]-FeCl4 has been utilized for the synthesis of a series of novel highly functionalized coumarinyl-pyrido[2,3-d]pyrimidine-2,4-dione derivatives (3a-3l) by the reactions of various 3-chloro-3-(2-oxo-2H-chromen-3-yl)acrylaldehydes (1) with functionalized aryl, 6-aminouracils. The major significant of the present procedure is the use of task-specific acidic ionic liquid which act as catalyst as well as reaction medium and thus avoiding use of organic solvent and/or protic acid catalyst. The other major advantages of the protocol are (i) shorter reaction time (1 h), (ii) easy work up procedure, (iii) excellent yields of products (91-94%), and (iv) recyclability of catalyst. The compounds (3a-3l) were identified using FT-IR, 1H NMR, and 13C NMR and mass spectroscopic studies.
Referência(s)