Revisiting the hallmarks of cancer.
2017; National Institutes of Health; Volume: 7; Issue: 5 Linguagem: Inglês
Autores
Yousef A. Fouad, Carmen Aanei,
Tópico(s)Cancer Cells and Metastasis
ResumoThe hallmarks of cancer described by Hanahan and Weinberg have proved seminal in our understanding of cancer's common traits and in rational drug design. Not free of critique and with understanding of different aspects of tumorigenesis coming into clearer focus in the recent years, we attempt to draw a more organized and updated picture of the cancer hallmarks. We define seven hallmarks of cancer: selective growth and proliferative advantage, altered stress response favoring overall survival, vascularization, invasion and metastasis, metabolic rewiring, an abetting microenvironment, and immune modulation, while highlighting some considerations for the future of the field.
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