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BIBTEX RIS

The Genomic Impact of European Colonization of the Americas

2019; Elsevier BV; Volume: 29; Issue: 23 Linguagem: Inglês

10.1016/j.cub.2019.09.076

ISSN

1879-0445

Autores

Linda Ongaro, Marília O. Scliar, Rodrigo Flores, Alessandro Raveane, Davide Marnetto, Stefania Sarno, Guido Alberto Gnecchi‐Ruscone, Marta E. Alarcón‐Riquelme, Étienne Patin, Pongsakorn Wangkumhang, Garrett Hellenthal, Miguel González‐Santos, Roy King, Anastasia Kouvatsi, Oleg Balanovsky, Elena Balanovska, Л. А. Атраментова, Shahlo Turdikulova, Sarabjit Mastana, Damir Marjanović, Lejla Mulahasanovic, Andreja Leskovac, Maria Fernanda Lima‐Costa, Alexandre C. Pereira, Maurício L. Barreto, Bernardo Lessa Horta, Nédio Mabunda, Celia A. May, Andrés Moreno‐Estrada, Alessandro Achilli, Anna Olivieri, Ornella Semino, Kristiina Tambets, Toomas Kivisild, Donata Luiselli, Antonio Torroni, Cristian Capelli, Eduardo Tarazona‐Santos, Mait Metspalu, Luca Pagani, Francesco Montinaro,

Tópico(s)

Genetic Associations and Epidemiology

Resumo

The human genetic diversity of the Americas has been affected by several events of gene flow that have continued since the colonial era and the Atlantic slave trade. Moreover, multiple waves of migration followed by local admixture occurred in the last two centuries, the impact of which has been largely unexplored. Here, we compiled a genome-wide dataset of ∼12,000 individuals from twelve American countries and ∼6,000 individuals from worldwide populations and applied haplotype-based methods to investigate how historical movements from outside the New World affected (1) the genetic structure, (2) the admixture profile, (3) the demographic history, and (4) sex-biased gene-flow dynamics of the Americas. We revealed a high degree of complexity underlying the genetic contribution of European and African populations in North and South America, from both geographic and temporal perspectives, identifying previously unreported sources related to Italy, the Middle East, and to specific regions of Africa.

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