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BIBTEX RIS

Himatanthus bracteatus stem extracts present anti-flavivirus activity while an isolated sesquiterpene glucoside present only anti-Zika virus activity in vitro

2019; Taylor & Francis; Volume: 35; Issue: 18 Linguagem: Inglês

10.1080/14786419.2019.1690487

ISSN

1478-6427

Autores

Marlene Lourenço da Silva, João Renato Stehmann, Mateus Sá Magalhães Serafim, Valdicley Vieira Vale, Douglas Costa Gontijo, Geraldo Célio Brandão, Erna Geessien Kroon, Alaı́de Braga de Oliveira,

Tópico(s)

Malaria Research and Control

Resumo

The hexane and ethanol extracts from Himatanthus bracteatus (Apocynaceae) stems were evaluated for antiviral activity against Zika virus, yellow fever virus and dengue virus 2 and for cytotoxicity in Vero cells by MTT assay. The ethanol extract showed good antiviral activity against the three viruses with selective indexes (SI) > 10 and its fractionation led to the isolation of the known plumieride that was active only against Zika virus (SI of 15.97).

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