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Endocrine Disruptors and the Risk of Lymphoma in a Multi- Centric European Study

2014; National Institute of Environmental Health Sciences; Volume: 2014; Issue: 1 Linguagem: Inglês

10.1289/isee.2014.o-016

2169-2181

Laura Costas, Claire Infante‐Rivard, Martie van Tongeren, Jan‐Paul Zock, Nikolaus Becker, Paolo Boffetta, Paul Brennan, Lenka Foretová, Marc Maynadié, CRB Ferdinand Cabanne, Anthony Staines, Alexandra Nieters, Pierluigi Cocco, Sílvia de Sanjosé,

Acute Lymphoblastic Leukemia research

Endocrine Disruptors and the Risk of Lymphoma in a Multi- Centric European StudyAbstract Number:2489 Laura Costas, Claire Infante-Rivard, Martie Van Tongeren, Jan-Paul Zock, Nikolaus Becker, Paolo Boffetta, Paul Brennan, Lenka Foretova, Marc Maynadie, CRB Ferdinand Cabanne, Anthony Staines, Alexandra Nieters, Pierluigi Cocco, and Silvia de Sanjose* Laura Costas Catalan Institute of Oncology, Spain, E-mail Address: [email protected] , Claire Infante-Rivard McGill University, Canada, E-mail Address: [email protected] , Martie Van Tongeren Institute of Occupational Medicine, United Kingdom , Jan-Paul Zock Netherlands Institute for Health Services Research, Netherlands , Nikolaus Becker Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 280, Germany , Paolo Boffetta Tisch Cancer Institute, Mount Sinai School of Medicine, United States , Paul Brennan IARC, International Agency for Research on Cancer, France , Lenka Foretova Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Czech Republic , Marc Maynadie Biological Hematology Unit , CRB Ferdinand Cabanne Universitary Hospital of Dijon and EA4184, University of Burgundy, France , Anthony Staines Public Health University College, Ireland , Alexandra Nieters Centre of Chronic Immunodeficiency, Molecular Epidemiology, University Medical Center Freiburg, Germany , Pierluigi Cocco Department of Public Health, Occupational Health Section, University of Cagliari, Italy , and Silvia de Sanjose* Catalan Institute of Oncology, Spain AbstractObjectives: Certain pesticides and solvents, which may have endocrine disrupting properties, have been associated with an increased risk of lymphoma. We explored if similar associations are observed for other industrial agents that potentially have endocrine disrupting effects.Methods: The Epilymph study is a case–control study carried out in 6 European countries from 1998 to 2004. We evaluated 2,457 controls and 2,313 lymphoma cases and subtypes. Lifetime occupational history was collected through face-to-face interviews. We applied a job-exposure matrix (JEM) for endocrine disruptors, to assess occupational exposures to polycyclic aromatic hydrocarbons, polychlorinated organic compounds, pesticides, phthalates, solvents, bisphenol-A, alkylphenols, brominated flame retardants, and metals (Brouwers et al. 2009).Results: Prevalence of ever occupationally exposed among controls ranged from 1% (bisphenol-A) to 45% (solvents). Exposure to endocrine disruptors for longer than 15 years was associated with higher odds of non-Hodgkin lymphoma (NHL; OR=1.21, 95%CI: 1.02- 1.43) and chronic lymphocytic leukemia (CLL; OR=1.42, 95%CI: 1.06-1.89) when compared to unexposed. Workers with recent exposures were at higher risk of NHL (OR=1.27, 95%CI=1.03-1.58) and multiple myeloma (MM; OR=1.67, 95%CI: 1.09-2.56), while associations were null if exposures occurred >15 years ago. Cumulative exposure (number of years exposed) to pesticides, phthalates, solvents, alkylphenols, and metals showed linear increases in risks for NHL, CLL and MM.Conclusions: We observed novel associations for prolonged exposures to phthalates, metals, as well as alkylphenols and lymphoma risk. Limitations in interpreting our findings include time- and country-related changes in exposure not reflected by the JEM, multiple comparisons and nondifferential misclassification, likely leading to the attenuation of estimates for binary and continuous exposures.