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Tribute to Paul M. Vanhoutte, MD, PhD (1940–2019)

2019; Lippincott Williams & Wilkins; Volume: 39; Issue: 12 Linguagem: Inglês

10.1161/atvbaha.119.313461

1524-4636

Chantal M. Boulanger, Oliver Baretella, Gilbert Blaise, Richard A. Bond, Yin Cai, C K Chan, Thierry Chataigneau, M. Chen, Hui Chen, Yanhua Cheng, Denis Clément, Richard A. Cohen, Michael J. Collis, A.H. Jan Danser, Jo G. R. De Mey, Charlotte Marie Simonne Detremmerie, Daniel Duprez, Michel Félétou, Nicolas Flavahan, Yuansheng Gao, Yumeng Guo, U. Hoeffner, Donald S. Houston, Ianto Boscheng Huang, Yü Huang, Stephane Iliano, Didier Junquéro, Zvonimir S. Katušić, Kimihiro Komori, Mary Y. K. Lee, Susan W.S. Leung, Zhuo-ming Li, Sophie Chaofan Liang, J Liu, Thomas F. Lüscher, Frederic Michel, Virginia M. Miller, Jean-Vivien Mombouli, Keith Morrison, Sheila M. Muldoon, Steve O’Rourke, Louis P. Perrault, Jean‐François Quignard, Nancy J. Rusch, Carlos F. Sánchez‐Ferrer, Valérie B. Schini‐Kerth, Kaikai Shen, Yi Shi, Erfei Song, Kiwi W.Y. Sun, Stefano Taddei, Eva Hoi Ching Tang, Meral Tuncer, Romana van den Ende, Yuri P. Vedernikov, Tony J. Verbeuren, Clinton Webb, André Weigert, Kenneth H.K. Wong, Cheng Xu, Kangmin Yang, Ying Fan, Thomas M. Zellers, Yingzi Zhao, Qian Zou, Hiroaki Shimokawa,

Cardiovascular Disease and Adiposity

HomeArteriosclerosis, Thrombosis, and Vascular BiologyVol. 39, No. 12Tribute to Paul M. Vanhoutte, MD, PhD (1940–2019) Free AccessObituaryPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessObituaryPDF/EPUBTribute to Paul M. Vanhoutte, MD, PhD (1940–2019) Chantal M. Boulanger, Oliver Baretella, Gilbert Blaise, Richard A. Bond, Yin Cai, Calvin K.Y. Chan, Thierry Chataigneau, Maggie Jie Chen, Hui Chen, Yanhua Cheng, Denis L. Clement, Richard A. Cohen, Michael Collis, A.H. Jan Danser, Jo de Mey, Charlotte M.S. Detremmerie, Daniel Duprez, Michel Feletou, Nicolas Flavahan, Yuansheng Gao, Yumeng Guo, Ute Hoeffner, Donald S. Houston, Ianto Boscheng Huang, Yu Huang, Stephane Iliano, Didier Junquero, Zvonimir S. Katusic, Kimihiro Komori, Mary Y.K. Lee, Susan W.S. Leung, Zhuoming Li, Sophie Chaofan Liang, Jacky Tsz Chiu Liu, Thomas F. Luscher, Frederic Michel, Virginia M. Miller, Jean-Vivien Mombouli, Keith Morrison, Sheila M. Muldoon, Steve O'Rourke, Louis Perrault, Jean Francois Quignard, Nancy J. Rusch, Carlos F. Sanchez-Ferrer, Valerie Schini-Kerth, Kaikai Shen, Yi Shi, Erfei Song, Kiwi W.Y. Sun, Stefano Taddei, Eva Hoi Ching Tang, Meral Tuncer, Romana van den Ende, Yuri Vedernikov, Tony J. Verbeuren, Clinton Webb, André Weigert, Kenneth H.K. Wong, Cheng Xu, Kangmin Yang, Fan Ying, Thomas Zellers, Yingzi Zhao, Qian Zou, Hiroaki Shimokawa and on behalf of Professor Paul M. Vanhoutte's former fellows Chantal M. BoulangerChantal M. Boulanger Correspondence to: Chantal Boulanger, PhD, Paris Cardiovascular Research Center INSERM UMR-970 56 rue Leblanc, F-75737 Paris Cedex 15. Email E-mail Address: [email protected] From the Université de Paris, PARCC, Inserm, France (C.M.B.) , Oliver BaretellaOliver Baretella Bern University Hospital, Bern, Switzerland (O.B.) , Gilbert BlaiseGilbert Blaise Université de Montréal, Canada (G.B.) , Richard A. BondRichard A. Bond University of Houston, TX (R.A.B.) , Yin CaiYin Cai University of Hong Kong, PRC (Y. Cai, H.C., Y. Cheng, Y. Guo, M.Y.K.L., S.W.S.L., S.C.L., J.T.C.L., K.W.Y.S., E.H.C.T., K.H.K.W., Q.Z.) , Calvin K.Y. ChanCalvin K.Y. Chan Tuen Mun Hospital, Hong Kong, PRC (C.K.Y.C.) , Thierry ChataigneauThierry Chataigneau University of Strasbourg, France (T.C.) , Maggie Jie ChenMaggie Jie Chen Shaoguan University, China (M.J.C.) , Hui ChenHui Chen University of Hong Kong, PRC (Y. Cai, H.C., Y. Cheng, Y. Guo, M.Y.K.L., S.W.S.L., S.C.L., J.T.C.L., K.W.Y.S., E.H.C.T., K.H.K.W., Q.Z.) , Yanhua ChengYanhua Cheng University of Hong Kong, PRC (Y. Cai, H.C., Y. Cheng, Y. Guo, M.Y.K.L., S.W.S.L., S.C.L., J.T.C.L., K.W.Y.S., E.H.C.T., K.H.K.W., Q.Z.) , Denis L. ClementDenis L. Clement University of Ghent, Belgium (D.L.C.) , Richard A. CohenRichard A. Cohen Whitaker Cardiovascular Institute, Boston, MA (R.A.C.) , Michael CollisMichael Collis Retiree, Barham, United Kingdom (M.C.) , A.H. Jan DanserA.H. Jan Danser Erasmus MC, Rotterdam, the Netherlands (A.H.J.D.) , Jo de MeyJo de Mey University of Southern Denmark (J.D.M.) , Charlotte M.S. DetremmerieCharlotte M.S. Detremmerie NYU Langone, New York (C.M.S.D.) , Daniel DuprezDaniel Duprez University of Minnesota, Minneapolis (D.D.) , Michel FeletouMichel Feletou Retiree, Paris, France (M.F.) , Nicolas FlavahanNicolas Flavahan Johns Hopkins University, Baltimore, MA (N.F.) , Yuansheng GaoYuansheng Gao Peking University, Beijing, PRC (Y. Gao) , Yumeng GuoYumeng Guo University of Hong Kong, PRC (Y. Cai, H.C., Y. Cheng, Y. Guo, M.Y.K.L., S.W.S.L., S.C.L., J.T.C.L., K.W.Y.S., E.H.C.T., K.H.K.W., Q.Z.) , Ute HoeffnerUte Hoeffner Glenmark Pharmaceuticals, Gröbenzell, Germany (U.H.) , Donald S. HoustonDonald S. Houston University of Manitoba, Winnipeg, Canada (D.S.H.) , Ianto Boscheng HuangIanto Boscheng Huang Chinese University of Hong Kong, Hong Kong, PRC (I.B.H., Y.H., F.Y.) , Yu HuangYu Huang Chinese University of Hong Kong, Hong Kong, PRC (I.B.H., Y.H., F.Y.) , Stephane IlianoStephane Iliano Sanofi R&D, Chilly Mazarin, France (S.I.) , Didier JunqueroDidier Junquero Pierre Fabre Health Care, Castres, France (D.J.) , Zvonimir S. KatusicZvonimir S. Katusic Mayo Clinic College of Medicine, Rochester, MN (Z.S.K.) , Kimihiro KomoriKimihiro Komori Nagoya University, Japan (K.K.) , Mary Y.K. LeeMary Y.K. Lee University of Hong Kong, PRC (Y. Cai, H.C., Y. Cheng, Y. Guo, M.Y.K.L., S.W.S.L., S.C.L., J.T.C.L., K.W.Y.S., E.H.C.T., K.H.K.W., Q.Z.) , Susan W.S. LeungSusan W.S. Leung University of Hong Kong, PRC (Y. Cai, H.C., Y. Cheng, Y. Guo, M.Y.K.L., S.W.S.L., S.C.L., J.T.C.L., K.W.Y.S., E.H.C.T., K.H.K.W., Q.Z.) , Zhuoming LiZhuoming Li Sun Yat-sen University, Guangzhou, China (Z.L.) , Sophie Chaofan LiangSophie Chaofan Liang University of Hong Kong, PRC (Y. Cai, H.C., Y. Cheng, Y. Guo, M.Y.K.L., S.W.S.L., S.C.L., J.T.C.L., K.W.Y.S., E.H.C.T., K.H.K.W., Q.Z.) , Jacky Tsz Chiu LiuJacky Tsz Chiu Liu University of Hong Kong, PRC (Y. Cai, H.C., Y. Cheng, Y. Guo, M.Y.K.L., S.W.S.L., S.C.L., J.T.C.L., K.W.Y.S., E.H.C.T., K.H.K.W., Q.Z.) , Thomas F. LuscherThomas F. Luscher Royal Brompton & Harefield Hospitals, London, United Kingdom (T.F.L.) , Frederic MichelFrederic Michel University of the Witwatersrand, Johannesburg, South Africa (F.M.) , Virginia M. MillerVirginia M. Miller Mayo Clinic, Rochester, MN (V.M.M.) , Jean-Vivien MombouliJean-Vivien Mombouli Laboratoire National de Santé Publique, Brazzaville, Congo (J.-V.M.) , Keith MorrisonKeith Morrison Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland (K.M.) , Sheila M. MuldoonSheila M. Muldoon Uniformed Services University, Bethesda, MD (S.M.M.) , Steve O'RourkeSteve O'Rourke North Dakota State University, Fargo (S.O.) , Louis PerraultLouis Perrault Institut de Cardiologie, Montréal, Canada (L.P.) , Jean Francois QuignardJean Francois Quignard Université de Bordeaux, France (J.F.Q.) , Nancy J. RuschNancy J. Rusch University of Arkansas for Medical Sciences, Little Rock (N.J.R.) , Carlos F. Sanchez-FerrerCarlos F. Sanchez-Ferrer Universidad Autonoma, Madrid, Spain (C.F.S.-F.) , Valerie Schini-KerthValerie Schini-Kerth Université de Strasbourg, Strasbourg, France (V.S.-K.) , Kaikai ShenKaikai Shen Shanghai University of Traditional Chinese Medicine, China (K.S.) , Yi ShiYi Shi Zhongshan Hospital Fudan University, China (Y.S.) , Erfei SongErfei Song Jinan University, Guangzhou, China (E.S.) , Kiwi W.Y. SunKiwi W.Y. Sun University of Hong Kong, PRC (Y. Cai, H.C., Y. Cheng, Y. Guo, M.Y.K.L., S.W.S.L., S.C.L., J.T.C.L., K.W.Y.S., E.H.C.T., K.H.K.W., Q.Z.) , Stefano TaddeiStefano Taddei University of Pisa, Italy (S.T.) , Eva Hoi Ching TangEva Hoi Ching Tang University of Hong Kong, PRC (Y. Cai, H.C., Y. Cheng, Y. Guo, M.Y.K.L., S.W.S.L., S.C.L., J.T.C.L., K.W.Y.S., E.H.C.T., K.H.K.W., Q.Z.) , Meral TuncerMeral Tuncer Baskent University, Ankara, Turkey (M.T.) , Romana van den EndeRomana van den Ende Retiree, Badhoevedorp, the Netherlands (R.v.d.E.) , Yuri VedernikovYuri Vedernikov Retiree, Galveston, TX (Y.V.) , Tony J. VerbeurenTony J. Verbeuren Servier Research Institute, Suresnes, France (T.J.V.) , Clinton WebbClinton Webb Medical College of Georgia, Augusta, GA (C.W.) , André WeigertAndré Weigert Hospital S. Cruz, University of Lisbon, Portugal (A.W.) , Kenneth H.K. WongKenneth H.K. Wong University of Hong Kong, PRC (Y. Cai, H.C., Y. Cheng, Y. Guo, M.Y.K.L., S.W.S.L., S.C.L., J.T.C.L., K.W.Y.S., E.H.C.T., K.H.K.W., Q.Z.) , Cheng XuCheng Xu Shenzhen University, China (C.X.) , Kangmin YangKangmin Yang University of Zurich, Switzerland (K.Y.) , Fan YingFan Ying Chinese University of Hong Kong, Hong Kong, PRC (I.B.H., Y.H., F.Y.) , Thomas ZellersThomas Zellers University of Texas Southwestern Medical Center, Dallas (T.Z.) , Yingzi ZhaoYingzi Zhao Chinese Academy of Sciences, Shenzhen, China (Y.Z.) , Qian ZouQian Zou University of Hong Kong, PRC (Y. Cai, H.C., Y. Cheng, Y. Guo, M.Y.K.L., S.W.S.L., S.C.L., J.T.C.L., K.W.Y.S., E.H.C.T., K.H.K.W., Q.Z.) , Hiroaki ShimokawaHiroaki Shimokawa Hiroaki Shimokawa, MD, PhD, Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan. Email E-mail Address: [email protected] Tohoku University, Sendai, Japan (H.S.). and on behalf of Professor Paul M. Vanhoutte's former fellows Originally published26 Nov 2019https://doi.org/10.1161/ATVBAHA.119.313461Arteriosclerosis, Thrombosis, and Vascular Biology. 2019;39:2445–2447Professor Paul M. Vanhoutte passed away at the age of 78 years on August 23, 2019. All our thoughts are with his family, his wife, children, and grandchildren.Professor Vanhoutte will be remembered as an internationally renowned figure in cardiovascular medicine and pharmacology for his major scientific contributions that unraveled the importance of endothelial cells regulating the underlying vascular smooth muscle in vascular health and disease and for his seminal discoveries that emphasized the complexity of that regulation. His scientific productivity included >669 original research articles, and 574 editorials, reviews, or book chapters in the cardiovascular field.Paul M. Vanhoutte was born in Belgium; he obtained his medical degree at the University of Ghent and his PhD degree at the University of Antwerp. His outstanding academic career took him to prestigious Professor positions at the Mayo Clinic in Rochester, Minnesota, and at Baylor College of Medicine in Houston, TX. During this time, he also was involved at the highest levels in the International Union of Basic and Clinical Pharmacology. Later on, he moved to the pharmaceutical industry as Vice-President of R&D at the Institut de Recherches Internationales Servier, in France. From 2003 and until this summer, he held several academic positions at the University of Hong Kong, including Chair Professor and Head of the Department of Pharmacology and Pharmacy. He also was Visiting Professor at 13 different universities across the world and an active member of numerous scientific academies and societies. He never retired.As many young research fellows, we were all attracted by his charismatic leadership, his profound passion, love of science, and his rare human and mentoring qualities. Throughout his life, Professor Vanhoutte expressed a genuine interest in the well-being of his fellows and in their scientific careers. He would encourage us by citing Alexander the Great "There is nothing impossible to him who will try." Professor Vanhoutte traveled extensively but was never more than a phone call or an email away, always available to discuss scientific results. We all remember his excitement when discovering new or unexpected results through his famous words "I feel a paper coming on, sharpen your pencils!" which would even further fuel our energy to gather the necessary data to complete the study.Some of us were with him at the beginning of his career when his interest was on catecholamines and the regulation of venous tone, working with Dr John Shepherd at the Mayo Clinic.1 Others joined his lab in the 80s, at the time of Robert Furchgott's discovery of the obligatory role of the endothelium as a regulator of smooth muscle function and remember Paul's profound admiration for Furchgott's scientific mind.2–6 Other fellows took part in his work on dysfunctional and regenerated endothelium that led to the discovery of the underlying molecular mechanisms.7–10 Others were with him during the search for endothelium-dependent contracting11–15 and hyperpolarizing factors16–18 and their role in health and disease.Professor Vanhoutte took much pride in organizing a series of scientific meetings titled Mechanisms of Vasodilatation. It was at the Fourth Mechanisms of Vasodilatation conference, held in Rochester in the summer of 1986, where Robert Furchgott and Louis Ignarro independently announced the finding that EDRF (endothelium-derived relaxing factor) was nitric oxide. Shortly thereafter, Professor Vanhoutte gained in a few years an international reputation for his work on EDRF, nitric oxide, and other endothelium-derived vasoactive factors in health and disease. He was the first to discover endothelium-dependent contractions, in particular in arteries exposed to hypertension. He was an extraordinary speaker, captivating his scientific audience until the end of his life, having given an address at Mechanisms of Vasodilatation in Rotterdam in May 2019. He was unique in constantly citing our names when describing our results at conferences, but he remained very humble regarding his own input; he even used to say that his only scientific contribution was to give his blood for experiments in the first article reporting endothelium-dependent responses to platelets. Professor Vanhoutte's scientific life centered on blood vessels, veins, and arteries; "the tissue never lies," he used to say when data were not what his fellow would expect from their experiment.Aside from the lab, Paul Vanhoutte lived well, enjoying good food, good wine, good laughs, and sometimes a cigar. He loved jokes and always had a new one to tell the audience. Throughout the years, and particularly at venues such as Experimental Biology, Mechanisms of Vasodilatation, and EDHF Meetings, his current and former fellows would meet with him for "PMV dinner parties" that were not to be missed. We are honored to have accompanied him on his scientific journey.Paul Vanhoutte will always be in our hearts.Download figureDownload PowerPointLeft, Photograph of Professor Paul M. Vanhoutte in 2015. Right, Professor Vanhoutte portrait at 60 with all his fellows' names. Drawing by Dr Tony Verbeuren at 60. Reproduced from Bond19 with permission. Copyright ©2001, Elsevier.DisclosuresNone.FootnotesFor Disclosures, see page 2447.Correspondence to: Chantal Boulanger, PhD, Paris Cardiovascular Research Center INSERM UMR-970 56 rue Leblanc, F-75737 Paris Cedex 15. Email chantal.[email protected]frHiroaki Shimokawa, MD, PhD, Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan. Email [email protected]med.tohoku.ac.jpReferences1. Shepherd JT, Vanhoutte PM: Veins and Their Control. Philadelphia, WB: Saunders Company; 1975.Google Scholar2. De Mey JG, Vanhoutte PM. Heterogeneous behavior of the canine arterial and venous wall. Importance of the endothelium.Circ Res. 1982; 51:439–447. doi: 10.1161/01.res.51.4.439LinkGoogle Scholar3. Vanhoutte PM. The endothelium–modulator of vascular smooth-muscle tone.N Engl J Med. 1988; 319:512–513. doi: 10.1056/NEJM198808253190809CrossrefMedlineGoogle Scholar4. Furchgott RF, Vanhoutte PM. Endothelium-derived relaxing and contracting factors.FASEB J. 1989; 3:2007–2018.CrossrefMedlineGoogle Scholar5. Vanhoutte PM. How we learned to say NO.Arterioscler Thromb Vasc Biol. 2009; 29:1156–1160. doi: 10.1161/ATVBAHA.109.190215LinkGoogle Scholar6. Vanhoutte PM, Zhao Y, Xu A, Leung SW. Thirty years of saying NO: sources, fate, actions, and misfortunes of the endothelium-derived vasodilator mediator.Circ Res. 2016; 119:375–396. doi: 10.1161/CIRCRESAHA.116.306531LinkGoogle Scholar7. Cohen RA, Shepherd JT, Vanhoutte PM. Inhibitory role of the endothelium in the response of isolated coronary arteries to platelets.Science. 1983; 221:273–274. doi: 10.1126/science.6574604CrossrefMedlineGoogle Scholar8. Shimokawa H, Aarhus LL, Vanhoutte PM. Porcine coronary arteries with regenerated endothelium have a reduced endothelium-dependent responsiveness to aggregating platelets and serotonin.Circ Res. 1987; 61:256–270. doi: 10.1161/01.res.61.2.256LinkGoogle Scholar9. Vanhoutte PM. Endothelial dysfunction and atherosclerosis.Eur Heart J. 1997; 18 (suppl E):E19–E29. doi: 10.1016/s0195-668x(97)90005-1CrossrefMedlineGoogle Scholar10. Vanhoutte PM, Shimokawa H, Feletou M, Tang EH. Endothelial dysfunction and vascular disease - a 30th anniversary update.Acta Physiol (Oxf). 2017; 219:22–96. doi: 10.1111/apha.12646CrossrefMedlineGoogle Scholar11. Rubanyi GM, Vanhoutte PM. Hypoxia releases a vasoconstrictor substance from the canine vascular endothelium.J Physiol. 1985; 364:45–56. doi: 10.1113/jphysiol.1985.sp015728CrossrefMedlineGoogle Scholar12. Vanhoutte PM, Leung SWS. Hypoxic augmentation: the tale of a strange contraction.Basic Clin Pharmacol Toxicol. 2019. doi: 10.1111/bcpt.13295. [Epub ahead of print]CrossrefMedlineGoogle Scholar13. Vanhoutte PM, Katusic ZS. Endothelium-derived contracting factor: endothelin and/or superoxide anion?Trends Pharmacol Sci. 1988; 9:229–230. doi: 10.1016/0165-6147(88)90146-0CrossrefMedlineGoogle Scholar14. Luscher TF, Vanhoutte PM. Endothelium-dependent responses in human blood vessels.Trends Pharmacol Sci. 1988; 9:181–184. doi: 10.1016/0165-6147(88)90035-1CrossrefMedlineGoogle Scholar15. Vanhoutte PM, Tang EH. Endothelium-dependent contractions: when a good guy turns bad!J Physiol. 2008; 586:5295–5304. doi: 10.1113/jphysiol.2008.161430CrossrefMedlineGoogle Scholar16. Feletou M, Vanhoutte PM. Endothelium-dependent hyperpolarization of canine coronary smooth muscle.Br J Pharmacol. 1988; 93:515–524. doi: 10.1111/j.1476-5381.1988.tb10306.xCrossrefMedlineGoogle Scholar17. Vanhoutte PM. Endothelium-dependent hyperpolarizations: the history.Pharmacol Res. 2004; 49:503–508. doi: 10.1016/j.phrs.2003.11.015CrossrefMedlineGoogle Scholar18. Félétou M, Vanhoutte PM. Endothelium-derived hyperpolarizing factor: where are we now?Arterioscler Thromb Vasc Biol. 2006; 26:1215–1225. doi: 10.1161/01.ATV.0000217611.81085.c5LinkGoogle Scholar19. Bond RA. Vanhoutte at 60.Trends in Pharmacol Sci. 2001; 22:P102. doi: 10.1016/S0165-6147(00)01649-7CrossrefGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetails December 2019Vol 39, Issue 12 Advertisement Article InformationMetrics © 2019 American Heart Association, Inc.https://doi.org/10.1161/ATVBAHA.119.313461PMID: 31770032 Originally publishedNovember 26, 2019 PDF download Advertisement