Portal de Periódicos da CAPES

Sensitivity of transcription factors to DNA methylation

2019; Portland Press; Volume: 63; Issue: 6 Linguagem: Inglês

10.1042/ebc20190033

1744-1358

Éléa Héberlé, Anaïs F. Bardet,

Cancer-related gene regulation

Abstract Dynamic binding of transcription factors (TFs) to regulatory elements controls transcriptional states throughout organism development. Epigenetics modifications, such as DNA methylation mostly within cytosine-guanine dinucleotides (CpGs), have the potential to modulate TF binding to DNA. Although DNA methylation has long been thought to repress TF binding, a more recent model proposes that TF binding can also inhibit DNA methylation. Here, we review the possible scenarios by which DNA methylation and TF binding affect each other. Further in vivo experiments will be required to generalize these models.