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The Exhaled Nitric Oxide (Feno) As A Screening Tool To Assess Air Pollution Exposition In An Elderly Population.

2015; National Institute of Environmental Health Sciences; Volume: 2015; Issue: 1 Linguagem: Inglês

10.1289/isee.2015.2015-1415

2169-2181

Luís Fernando Amato‐Lourenço, Bianca Bonetto Moreno Garcia, Pamela Souza De Almeida, Douglas Rene Rocha Silva, Martha Cristina Motta Godinho Neto, Thaís Mauad, Paulo Hilário Nascimento Saldiva, Maria Eugênio Carretero, Regiani Carvalho-Oliveira,

Air Quality and Health Impacts

The region of Vale do Rio Cabuçu, with 300,000 inhabitants, is one of most impacted area by air pollution in São Paulo City. In this area there are great air pollution sources as the International Airport at Guarulhos, the Fernão Dias highway and the Fernão Dias Cargo Terminal. In this study, we aim to evaluate the effects of air pollution on respiratory symptoms and pulmonary inflammation of resident population with age over 55 years. Methodology: For this study we selected an area of the 4 km2 comprising the Fernão Dias highway and Fernão Dias Cargo terminal. Forty volunteers, 07 men and 33 women were selected from an initial 1,220 study area residents considering a homogenous spatial distribution. For the respiratory symptoms investigation was used the International Study of Asthma and Allergies in Childhood Questionnaire (ISAAC). The pulmonary inflammation was investigated by the measurement of the exhaled nitric oxide (FENO). Passive monitoring was used for the quantification of Nitrogen Dioxide (NO2) and Ozone (O3) in outside of each residence of volunteers. The association between FENO (dependent variable), ISACC questionnaire variables, passive NO2 and O3 was tested by generalized linear models (GLM). The GLM was fitted using log-link function and Poisson distribution. Results: The increase of 1 ppm of O3 was associated with an increase in FENO of 1.023 (95% CI: 1.017 – 1.030) and 1 ppm of NO2 with 1.011 (95% CI: 1.008 – 1.015) in a model adjusted for sex, age and passive smoking (p