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Cytokines in Inflammatory Disease

2019; Multidisciplinary Digital Publishing Institute; Volume: 20; Issue: 23 Linguagem: Inglês

10.3390/ijms20236008

1661-6596

Shinwan Kany, Jan Tilmann Vollrath, Borna Relja,

Autoimmune and Inflammatory Disorders Research

This review aims to briefly discuss a short list of a broad variety of inflammatory cytokines. Numerous studies have implicated that inflammatory cytokines exert important effects with regard to various inflammatory diseases, yet the reports on their specific roles are not always consistent. They can be used as biomarkers to indicate or monitor disease or its progress, and also may serve as clinically applicable parameters for therapies. Yet, their precise role is not always clearly defined. Thus, in this review, we focus on the existing literature dealing with the biology of cytokines interleukin (IL)-6, IL-1, IL-33, tumor necrosis factor-alpha (TNF-α), IL-10, and IL-8. We will briefly focus on the correlations and role of these inflammatory mediators in the genesis of inflammatory impacts (e.g., shock, trauma, immune dysregulation, osteoporosis, and/or critical illness).