Portal de Periódicos da CAPES

The complex challenges of HIV vaccine development require renewed and expanded global commitment

2019; Elsevier BV; Volume: 395; Issue: 10221 Linguagem: Inglês

10.1016/s0140-6736(19)32682-0

1474-547X

Linda‐Gail Bekker, Roger Tatoud, François Dabis, Mark B. Feinberg, Pontiano Kaleebu, Mary Marovich, Thumbi Ndung’u, Nina D. Russell, Jeremiah Johnson, Maureen Luba, Anthony S. Fauci, Lynn Morris, Giuseppe Pantaleo, Susan Buchbinder, Glenda Gray, Johan Vekemans, Jerome H. Kim, Yves Lévy, Lawrence Corey, Robin J. Shattock, Michael Makanga, Carolyn Williamson, Carl W. Dieffenbach, Maureen M. Goodenow, Yiming Shao, Silvija I. Staprans, Mitchell Warren, Margaret I. Johnston,

Vaccine Coverage and Hesitancy

Despite substantial progress in understanding and treating HIV/AIDS, existing tools have not effectively controlled the epidemic, and the potential threat of resurgence looms as the largest cohort of young people in history enters early adulthood. 1 Bekker L-G Alleyne G Baral S et al. Advancing global health and strengthening the HIV response in the era of the Sustainable Development Goals: the International AIDS Society–Lancet Commission. Lancet. 2018; 392: 312-358 Summary Full Text Full Text PDF PubMed Scopus (155) Google Scholar Treatment alone will not end the epidemic. 2 Havlir DV Balzer LB Charlebois ED et al. HIV testing and treatment with the use of a community health approach in rural Africa. N Engl J Med. 2019; 381: 219-229 Crossref PubMed Scopus (105) Google Scholar , 3 Makhema J Wirth KE Pretorius Holme M et al. Universal testing, expanded treatment, and incidence of HIV infection in Botswana. N Engl J Med. 2019; 381: 230-242 Crossref PubMed Scopus (105) Google Scholar , 4 Hayes R Ayles H Beyers N et al. HPTN 071 (PopART): rationale and design of a cluster-randomised trial of the population impact of an HIV combination prevention intervention including universal testing and treatment—a study protocol for a cluster randomised trial. Trials. 2014; 15: 57 Crossref PubMed Scopus (150) Google Scholar The International AIDS Society –Lancet Commission 1 Bekker L-G Alleyne G Baral S et al. Advancing global health and strengthening the HIV response in the era of the Sustainable Development Goals: the International AIDS Society–Lancet Commission. Lancet. 2018; 392: 312-358 Summary Full Text Full Text PDF PubMed Scopus (155) Google Scholar recommends that global treatment efforts should be complemented with stronger investments in primary prevention, including research to accelerate the development of a preventive vaccine. Indeed, even a partially effective vaccine could help to change the course of the HIV epidemic and have a substantial public health impact. 5 Corey L Gray GE Preventing acquisition of HIV is the only path to an AIDS-free generation. Proc Natl Acad Sci USA. 2017; 114: 3798-3800 Crossref PubMed Scopus (13) Google Scholar , 6 de Montigny S Adamson BJS Mâsse BR et al. Projected effectiveness and added value of HIV vaccination campaigns in South Africa: a modeling study. Sci Rep. 2018; 86066 Crossref PubMed Scopus (13) Google Scholar , 7 Phillips AN Cambiano V Nakagawa F et al. Potential future impact of a partially effective HIV vaccine in a southern African setting. PLoS One. 2014; 9e107214 Crossref PubMed Scopus (16) Google Scholar , 8 Selinger C Bershteyn A Dimitrov DT et al. Targeting and vaccine durability are key for population-level impact and cost-effectiveness of a pox-protein HIV vaccine regimen in South Africa. Vaccine. 2019; 37: 2258-2267 Crossref PubMed Scopus (7) Google Scholar