Aporphine Alkaloids from Guatteria spp. with Leishmanicidal Activity
2003; Thieme Medical Publishers (Germany); Volume: 69; Issue: 7 Linguagem: Inglês
10.1055/s-2003-41126
ISSN1439-0221
AutoresHéctor Montenegro, Marcelino Gutiérrez, Luz Romero, Eduardo Ortega-Barrı́a, Todd L. Capson, Luis Cubilla‐Rios,
Tópico(s)Insect Pest Control Strategies
ResumoFractionation of Guatteria amplifolia yielded the alkaloids xylopine (1), nornuciferine (4), lysicamine (6), and laudanosine (5). Fractionation of Guatteria dumetorum yielded the alkaloids cryptodorine (2) and nornantenine (3). Compounds 1 - 4 demonstrated significant activity against Leishmania mexicana and L. panamensis. Xylopine (1) was among the most active compounds (LD50 = 3 μM) and showed a 37-fold higher toxicity towards L. mexicana than macrophages, the regular host cells of Leishmania spp.
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