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Lactose drives Enterococcus expansion to promote graft-versus-host disease

2019; American Association for the Advancement of Science; Volume: 366; Issue: 6469 Linguagem: Inglês

10.1126/science.aax3760

1095-9203

Christoph K. Stein‐Thoeringer, Katherine Nichols, Amina Lazrak, Melissa D. Docampo, Ann E. Slingerland, John Slingerland, Annelie Clurman, Gabriel K. Armijo, Antonio L. C. Gomes, Yusuke Shono, Anna Staffas, Marina Burgos da Silva, Sean M. Devlin, Kate A. Markey, Danica Bajic, R. Pinedo, Anastasia Tsakmaklis, Eric R. Littmann, Alessandro Pastore, Ying Taur, Sébastien Monette, Maria E. Arcila, Amanda J. Pickard, Molly Maloy, Roberta J. Wright, Luigi A. Amoretti, Emily Fontana, Dung Pham, Mohamed A. Jamal, Daniela Weber, Anthony D. Sung, Daigo Hashimoto, Christof Scheid, João B. Xavier, Julia A. Messina, Kristi Romero, M. Lew, Amy Bush, Lauren Bohannon, Kasumi Hayasaka, Yuta Hasegawa, Maria J. G. T. Vehreschild, Justin R. Cross, Doris M. Ponce, Miguel-Ángel Perales, Sergio Giralt, Robert R. Jenq, Takanori Teshima, Ernst Holler, Nelson J. Chao, Eric G. Pamer, Jonathan U. Peled, Marcel R.M. van den Brink,

Digestive system and related health

Disruption of intestinal microbial communities appears to underlie many human illnesses, but the mechanisms that promote this dysbiosis and its adverse consequences are poorly understood. In patients who received allogeneic hematopoietic cell transplantation (allo-HCT), we describe a high incidence of enterococcal expansion, which was associated with graft-versus-host disease (GVHD) and mortality. We found that