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Establishment of Wolbachia Strain wAlbB in Malaysian Populations of Aedes aegypti for Dengue Control

2019; Elsevier BV; Volume: 29; Issue: 24 Linguagem: Inglês

10.1016/j.cub.2019.11.007

1879-0445

W A Nazni, Ary A. Hoffmann, Noor Afizah Ahmad, Yoon Ling Cheong, Maria Vittoria Mancini, Nick Golding, Ghazali M. R. Kamarul, Mohd A. K. Arif, Hasim Thohir, Halim NurSyamimi, M. Zabari ZatilAqmar, Mazni NurRuqqayah, Amran NorSyazwani, Azmi Faiz, Francis-Rudin M.N. Irfan, Subramaniam Rubaaini, Nasir Nuradila, Nasir M. N. Nizam, Saidin M. Irwan, Nancy M. Endersby‐Harshman, Vanessa L. White, Thomas H. Ant, Christie S. Herd, Asim H. Hasnor, Rahman AbuBakar, Dusa M. Hapsah, Khadijah Khairuddin, Denim Kamilan, Lee Soo Cheng, Yusof M. Paid, Fadzilah Kamaludin, Topek Omar, Balvinder Singh Gill, Han Lim Lee, Steven P. Sinkins,

Insect and Pesticide Research

Dengue has enormous health impacts globally. A novel approach to decrease dengue incidence involves the introduction of Wolbachia endosymbionts that block dengue virus transmission into populations of the primary vector mosquito, Aedes aegypti. The wMel Wolbachia strain has previously been trialed in open releases of Ae. aegypti; however, the wAlbB strain has been shown to maintain higher density than wMel at high larval rearing temperatures. Releases of Ae. aegypti mosquitoes carrying wAlbB were carried out in 6 diverse sites in greater Kuala Lumpur, Malaysia, with high endemic dengue transmission. The strain was successfully established and maintained at very high population frequency at some sites or persisted with additional releases following fluctuations at other sites. Based on passive case monitoring, reduced human dengue incidence was observed in the release sites when compared to control sites. The wAlbB strain of Wolbachia provides a promising option as a tool for dengue control, particularly in very hot climates.