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Hypoxia as a risk factor for arrhythmias in patients with chronic obstructive pulmonary disease and heart failure

2019; Lippincott Williams & Wilkins; Linguagem: Inglês

10.1183/13993003.congress-2019.pa4440

1531-5487

Arturo Tejeda Arturo, Luis Hernández Urquieta, Dulce González Islas, Aimeé Flores Vargas, Alan Ibarra Fernández, Angelia Jiménez Valentín, Roberto Dávila Ramos, Andrea Samantha Hernández López, Yuridia Pilotzi Montiel, Rocío Sánchez Santillan,

Chronic Obstructive Pulmonary Disease (COPD) Research

Introduction: Arrhythmias are present in Chronic Obstructive Pulmonary Disease (COPD) and heart failure (HF) patients, no study has been found where the prevalence and risk of arrhythmias present in both entities and their relation to hypoxia are determined, which could explain the biggest morbidity mortality when they coexist. Objective: To determine if hypoxia is a risk factor for arrhythmias in COPD and HF patients. Methods: Cross-sectional study, patients with COPD and / or HF diagnosis were included, asthma and cancer subjects were excluded. Arrhythmias were determinate by 24-hour Holter electrocardiogram and hypoxia by 24-hour pulse oximetry. Results: 98 patients were evaluated, divided into (HF+COPD, COPD and HF). Subjects with COPD + HF had a higher prevalence of ventricular premature beats (VPB) > at 1% (of the total beats in the study) (35.15 vs 23.26 and 7.69, p = 0.15 respectively), R/T phenomenon (41.46 vs 23.08 and 20.93, p=0.10 respectively) compared to the other groups. The rest of the variables were not statistically significant. Subjects with a longer desaturation time (> 327 minutes/day) had major risk to arrhythimias: atrial fibrillation, OR: 4.04, CI 0.82-19.88, supraventricular tachycardia,OR:2.83, CI95%: 0.92-8.64, paired extraheart beats OR: 3.31, CI95%: 1.1-9.91, sinus tachycardia OR: 3.58, CI95%: 1.02-12.59, and VPB > 1% OR: 2.51,CI95%: 0.08-7.82 compared with subjects with low desaturation time(<327 minutes/day) adjusting for age, sex, LVEF and oxygen use. Conclusions: COPD and HF concomitant had higher prevalence of arrhythmias. The risk of arrhythmias increases in long desaturation time.