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Synthesis, characterization and antimicrobial activity of Cr (III), Co (II) and Ni (II) complexes with 2-thiazoline-2-tiol derivative ligands against bacteria and yeasts of clinical importance

2019; Brazilian Academy of Sciences; Volume: 91; Issue: 4 Linguagem: Inglês

10.1590/0001-376520181077

1678-2690

Karina Marjorie Silva Herrera, Lorena Sales Ferreira, Alysson V. Braga, Juliano P. Souza, Jéssica Tauany Andrade, Adriana Cristina Soares, Luís Fernando Soares, Rafael César Russo Chagas, Jaqueline Maria Siqueira Ferreira,

Synthesis and Characterization of Heterocyclic Compounds

Four novel Cr (III), Co (II) and Ni (II) complexes with 2-thiazoline-2-tiol derivative ligands were synthesized and characterized using elemental, physiochemical, and spectroscopy analytical methods. The results showed the formation of ligands coordinated by sulfur atoms of the C = S bond to the L1 ligand and by the sulfur atom of the C-S bond and/or nitrogen of the intra C-ring bond of the L2 ligand. The activity of the complexes against Gram-negative, Gram-positive bacteria and yeasts of clinical importance was evaluated by broth microdilution method. The best result was obtained to L2-Ni compound against E. cloacae (Minimal Inhibitory Concentration (MIC) = 62.5 µg/mL). Additionally, the compounds showed anti-Candida activity (MIC values ranging from 250 to 500 µg/mL), except the L1-Cr that was not active against any tested microorganism.