Portal de Periódicos da CAPES

Artigo Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

Lower Insulin-Dose Adjusted A1c (IDAA1c) Is Associated With Less Complications in Individuals With Type 1 Diabetes Treated With Hematopoetic Stem-Cell Transplantation and Conventional Therapy

2019; Frontiers Media; Volume: 10; Linguagem: Inglês

10.3389/fendo.2019.00747

1664-2392

Jaquellyne Gurgel Penaforte-Saboia, Carlos Eduardo Barra Couri, Virgínia Oliveira Fernandes, Ana Paula Dias Rangel Montenegro, Lívia Aline de Araújo Batista, Lenita Zajdenverg, Carlos Antônio Negrato, Kelen Cristina Ribeiro Malmegrim, Daniela A. Moraes, Juliana Bernardes Elias Dias, Maria Carolina Oliveira, Akhtar Hussain, Marília Brito Gomes, Renan Magalhães Montenegro,

Diabetes and associated disorders

OBJECTIVE: To evaluate the association between insulin-dose adjusted A1C (IDAA1c) and microvascular complications (MC) and hypoglycemia in a representative Brazilian population of Type 1 diabetes mellitus (T1DM) patients. RESEARCH DESIGN AND METHODS: This was a cross-sectional study based on a previous study, “Microvascular Complications in Type 1 Diabetes: a comparative analysis of patients treated with autologous nonmyeloablative hematopoietic stem-cell transplantation (AHST) and conventional medical therapy (CT)”. The 168 patients in that study (144 from CT plus 24 from AHST) were re-subdivided into two groups, according to their IDAA1c values (30 patients had IDAA1c ≤9; 138 had IDAA1c >9). Then, the prevalence of MC (diabetic renal disease, neuropathy, and retinopathy), hypoglycemia (blood glucose 9 group had at least one complication (p =0.044). Regarding hypoglycemic events, the proportion of individuals who reported at least 1 episode of hypoglycemia in the last month was 43.3% and 64.7% from the IDAA1c ≤9 and IDAA1c >9 groups, respectively (p=0.030). Regarding severe hypoglycemia, the proportion of patients presenting at least 1 episode in the last month and the rate of episode/patient/month were similar between groups (6.7% vs 13.2%; p= 0.535; and 0.1/patient/month vs 0,25/patient/month; p= 0.321). CONCLUSION: In a representative Brazilian population of T1DM patients, those with IDAA1c ≤9 presented a lower frequency of MC, as well as fewer episodes of hypoglycemia, in the month prior to the analysis.