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Anti-immunoglobulin E for the treatment of allergic disease

2001; Lippincott Williams & Wilkins; Volume: 1; Issue: 1 Linguagem: Inglês

10.1097/01.all.0000010992.10510.21

1528-4050

William W. Busse, William A Neaville,

Food Allergy and Anaphylaxis Research

IgE plays a central role in allergic disease and participates in the associated inflammatory process. A mainstay of treatment of allergic disease, including asthma, is allergen avoidance and treatment of symptoms. Presently, the most effective treatments for allergic diseases are directed towards a regulation of the inflammatory process with corticosteroids. An exciting new approach is anti-IgE (rhuMAb-E25), which would regulate the allergic process at the level of IgE. The following information will review recent experiences with anti-IgE and discuss the conditions in which this approach may be effective.