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Hydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER Registry

2019; Oxford University Press; Volume: 59; Issue: 8 Linguagem: Inglês

10.1093/rheumatology/kez562

1462-0332

Natalia Mena‐Vázquez, Antonio Fernández‐Nebro, José María Pego‐Reigosa, María Galindo, A. M. Anzola Alfaro, Esther Uriarte-Isacelay, Alejandro Olivé-Marqués, Elena Aurrecoechea, Mercedes Freire, Eva Tomero, María Jesús García-Villanueva, Claudia Stoye, Esteban Salas-Heredia, J. A. Bernal, Eva Salgado, Ricardo Blanco, Francisco J. Nóvoa, Mónica Ibáñez‐Barceló, Vicente Torrente-Segarra, Javier Narváez, Joan Calvet, Clara Moriano Morales, Tomás R. Vázquez-Rodríguez, Paloma García de la Peña, C. Bohórquez Heras, José Luís Andreu, Tatiana Cobo‐Ibáñez, Gema Bonilla, Nuria Lozano‐Rivas, Carlos Montilla, Francisco Javier Toyos, José Luís Marenco de la Fuente, Lorena Expósito, María Esther Ruiz-Lucea, Elia Vals, Javier Manero-Ruiz, J. A. Bernal, Íñigo Rúa‐Figueroa,

Blood groups and transfusion

Abstract Objectives This article estimates the frequency of polyautoimmunity and associated factors in a large retrospective cohort of patients with SLE. Methods RELESSER (Spanish Society of Rheumatology Lupus Registry) is a nationwide multicentre, hospital-based registry of SLE patients. This is a cross-sectional study. The main variable was polyautoimmunity, which was defined as the co-occurrence of SLE and another autoimmune disease, such as autoimmune thyroiditis, RA, scleroderma, inflammatory myopathy and MCTD. We also recorded the presence of multiple autoimmune syndrome, secondary SS, secondary APS and a family history of autoimmune disease. Multiple logistic regression analysis was performed to investigate possible risk factors for polyautoimmunity. Results Of the 3679 patients who fulfilled the criteria for SLE, 502 (13.6%) had polyautoimmunity. The most frequent types were autoimmune thyroiditis (7.9%), other systemic autoimmune diseases (6.2%), secondary SS (14.1%) and secondary APS (13.7%). Multiple autoimmune syndrome accounted for 10.2% of all cases of polyautoimmunity. A family history was recorded in 11.8%. According to the multivariate analysis, the factors associated with polyautoimmunity were female sex [odds ratio (95% CI), 1.72 (1.07, 2.72)], RP [1.63 (1.29, 2.05)], interstitial lung disease [3.35 (1.84, 6.01)], Jaccoud arthropathy [1.92 (1.40, 2.63)], anti-Ro/SSA and/or anti-La/SSB autoantibodies [2.03 (1.55, 2.67)], anti-RNP antibodies [1.48 (1.16, 1.90)], MTX [1.67 (1.26, 2.18)] and antimalarial drugs [0.50 (0.38, 0.67)]. Conclusion Patients with SLE frequently present polyautoimmunity. We observed clinical and analytical characteristics associated with polyautoimmunity. Our finding that antimalarial drugs protected against polyautoimmunity should be verified in future studies.