Produção Nacional
Evaluation of potential use of Cymbopogon sp. essential oils, (R)-citronellal and N-citronellylamine in cancer chemotherapy
2013; Volume: 6; Issue: 4 Linguagem: Inglês
ISSN
1940-6223
AutoresSimone C. Stone, Flávia Aleixo Vasconcellos, Eder J. Lenardão, Raíssa Cardoso Amaral, Raquel G. Jacob, Fábio Pereira Leivas Leite,
Tópico(s)Phytochemistry and Biological Activities
ResumoSummary. Essential oil of Cymbopogon citratus (lemongrass) and Cymbopogon nardus (citronella), as well as the monoterpenic aldehyde citronellal and its chemically modified product, C37A ( N -citronellylamine), were evaluate for their cytotoxic potential. Two cell lines were used, a breast cancer cell line (MCF-7 - ATCC HTB-22) and a non-tumorigenic cell line (Vero - ATCC CRL-1586). Using the crystal violet assay for evaluate cell viability, we observed that all tested compounds demonstrated cytotoxicity for both cell lines, however with different intensities. Lemongrass oil was cytotoxic in similar way for both cell lines, while the others presented higher cytotoxic response to the tumor cell MCF-7, being citronellal a high selective product. The chemical modification of citronellal, that originated the C37A, promoted higher cytotoxic effects but no selectivity. Industrial relevance. The Cymbopogon genus has demonstrated important health feature. Essential oil of lemongrass, a plant of this genus, shows antitumor properties; however, the essential oil of citronella, a close related plant, does not have similar activity known, as well as its monoterpenic aldehyde component, citronellal. Here we show the potential of these products, especially citronellal, as possible new candidates for further investigation for breast cancer therapy. Keywords. Breast cancer; citronellal, essential oil; N -citronellylamine; medicinal plants
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