Portal de Periódicos da CAPES

Serological Profile of Hepatitis B in Children after the Introduction of Its Vaccination in Burkina Faso

2019; Multidisciplinary Digital Publishing Institute; Volume: 11; Issue: 4 Linguagem: Inglês

10.4081/pr.2019.8248

2036-7503

Makoura Barro, Diane Valéa, Saga Alain Ouermi, Sanata Sessouma, Bintou Sanogo, Ibrahim Ad Bafa Ouattara, Abdoul–Salam Ouédraogo, Boubacar Nacro, G. Moyen,

Viral Infections and Outbreaks Research

Viral hepatitis B is a public health issue. We establish the children serological profile of hepatitis B in Bobo-Dioulasso, six years after the introduction of hepatitis B vaccine into the Expanded Program on Immunization. This was a descriptive study of prospective data collection carried out in the Department of Pediatrics and the laboratory of virology of the Centre MURAZ of Bobo-Dioulasso between March 2013 and May 2013. Blood samples were made in search of the following hepatitis B serological markers: anti-HBcAb total, HBsAg, Ac anti-HBs, HBeAg, AcHBs, IgM anti-HBc total. The ELISA method with the Monolisa BIORAD reagents was used. A total of 2015 children were included, 1026 (50, 9%) boys and 989 (49.1%) girls, at an average age of 58±48 months. Out of these 2015 children, 53 (2.6%) were positive to HBsAg including 19 vaccinated cases, one child has received 3 doses plus 1 booster dose of hepatitis B vaccine. We found no statistically significant difference in the carriage of serologic markers of hepatitis B between the unvaccinated group and the vaccinated group. Large-scale studies should be carried out in Burkina Faso to see the real impact of vaccination on the health of our populations.