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Dose-related Effects of Resveratrol in Different Models of Pulmonary Arterial Hypertension: A Systematic Review

2019; Bentham Science Publishers; Volume: 16; Issue: 3 Linguagem: Inglês

10.2174/1573403x15666191203110554

1875-6557

Andressa Coelho Ferreira, Jerdianny Silva Serejo, Rafael Durans, Jadna Maryane Pereira Costa, Antonio Woodson Santos Maciel, Adeilson Serra Mendes Vieira, Carlos Alberto Alves Dias Filho, Carlos José Moraes Dias, Maria Rosa Quaresma Bomfim, Cristiano Teixeira Mostarda, Janaína de Oliveira Brito-Monzani,

Cardiovascular Function and Risk Factors

Background: Pulmonary Arterial Hypertension (PAH) is a severe and progressive disease of pulmonary arterioles. This pathology is characterized by elevation of the pulmonary vascular resistance and pulmonary arterial pressure, leading to right heart failure and death. Studies have demonstrated that resveratrol possesses a protective effect on the mechanisms related to the genesis of the PAH-induced by different models. Keywords: Pulmonary hypertension, resveratrol, drug therapy, administration and dosage, inflammation, oxidative stress, right ventricular failure.