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Antitumor Activity and Antioxidant Status of Symplocos racemosa Roxb Against Ehrlich Ascites Carcinoma in Swiss Albino Mice

2010; Volume: 1; Issue: 3 Linguagem: Inglês

0975-8585

M. Vijayabaskaran, Amol K. Badkhal, Babu Gajendran, P. Sivakumar, Pandurangan Perumal, T. Sivakumar, R. Sampathkumar, B. Jayakar,

Phytochemistry and Biological Activities

Antitumor and antioxidant status of ethanol extract (100 and 200mg/kg) of Symplocos racemosa (EESR) was evaluated against Ehrlich ascites carcinoma (EAC) bearing swiss albino mice. Acute and short term toxicity studies were performed initially in order to ascertain the safety of EESR. After 24 h of tumor inoculation, the extract was administered daily for 14 days intraperitoneally. After administration of last dose followed by 18 h fasting, the mice were sacrificed for observation of antitumor activity. The effect of EESR on the growth of transplantable murine tumor, life span of EAC bearing mice, hematological profile and liver biochemical parameters (lipid peroxidation, antioxidant enzymes) were estimated. Treatment with EESR decreased the tumor volume and viable cell count thereby increasing the lifespan of EAC bearing mice and brought back the hematological parameter more or less normal level. The effect of EESR also decreases the level of lipid peroxidation and increased the levels of catalase (CAT). The present work indicates that the ethanol extract of Symplocos racemosa exhibited antitumor effect by modulating lipid peroxidation and augmenting anti-oxidant defense system in EAC bearing mice.