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Anticancer Potential of Palladium(II) Complexes With Schiff Bases Derived from 4-Aminoacetophenone Against Melanoma In Vitro

2019; International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts; Volume: 39; Issue: 12 Linguagem: Inglês

10.21873/anticanres.13884

1791-7530

Luís Eduardo Sarto, Elba Pereira de Góis, GABRIELA GOMES DE ANDRADE, MATEUS SILVEIRA DE ALMEIDA, Jennifer Tavares Jacon Freitas, ANTÔNIO DE SOUZA REIS JÚNIOR, Lílian Pereira Franco, Cláudia Torres, Eduardo Tonon de Almeida, Cibele Marli Cação Paiva Gouvêa,

Synthesis and biological activity

Background/Aim: Melanoma represents a big challenge for clinical treatment. Besides being the most aggressive and the deadliest form of skin cancer, it is often refractory to commonly used anticancer drugs. Hence, developing new anti-cancer agents is crucial to improve refractory melanoma treatment. Studies using palladium(II) complexes have reported antitumor effects on cancer cells. In this study, we aimed to determine the cytotoxic effect of three novel synthesized Pd(II) complexes with Schiff bases derived from 4-aminoacetophenone on the MDA-MB-435 melanoma cell line. Materials and Methods: Cells were treated with ligand and Pd(II) complexes. Cell viability, morphology and death induction upon treatment were examined. Results: Novel synthesized Pd(II) complexes led to decreased viability of cells. They also induced morphological alterations and cell death, mainly in the C3 complex. Conclusion: The novel synthesized complexes have a significant cytotoxic effect on cell line MDA-MB-435, especially C3 and can be considered as an antitumor agent for further studies.