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Vitamin B6 reduces oxidative stress in lungs and liver in experimental sepsis

2019; Brazilian Academy of Sciences; Volume: 91; Issue: 4 Linguagem: Inglês

10.1590/0001-3765201920190434

1678-2690

Amanda Della Giustina, Lucinéia Gainski Danielski, MICHELE M. NOVOCHADLO, Mariana Pereira de Souza Goldim, Larissa Joaquim, Kiuanne Lino Lobo Metzker, Raquel Jaconi De Carli, Taís Luise Denicol, Thainá Cidreira, Thaynan Cunha Vieira, Fabrícia Petronilho,

Intensive Care Unit Cognitive Disorders

Sepsis is a life-threatening organ dysfunction induced by a disrupted host response to infecting pathogens. Inflammation and oxidative stress are intrinsically related to sepsis progression and organ failure. Vitamin B6 is an important cellular cofactor for metabolic processes and has anti-inflammatory and antioxidant properties. We aimed at evaluating the effect of vit B6 on inflammation and oxidative stress markers in the liver and lung of rats subjected to a relevant animal model of polymicrobial sepsis. Adult male Wistar rats were submitted to cecal ligation and perforation model and immediately after sepsis induction, vit B6 was administered as a single dose (600 mg/kg, subcutaneous). Twenty-four hours later, the lung and liver were harvest for neutrophil infiltration, oxidative markers to lipids and protein and antioxidant activity of endogenous enzyme. Vitamin B6 diminished neutrophil infiltration in both organs, oxidative markers in the liver and restored catalase activity levels in the lung of septic animals. Vitamin B6 exerts anti-inflammatory and antioxidant effects in peripheral organs after polymicrobial sepsis.