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Passive exposure of non-smokers to E-Cigarette aerosols: Sensory irritation, timing and association with volatile organic compounds

2019; Elsevier BV; Volume: 182; Linguagem: Inglês

10.1016/j.envres.2019.108963

1096-0953

Anna Tzortzi, Stephanie Teloniatis, George Matiampa, Gerasimos Bakelas, Chara Tzavara, Vergina Konstantina Vyzikidou, Constantine Vardavas, Panagiotis Behrakis, Esteve Fernández, Esteve Fernández, Yolanda Castellano, Marcela Fu, Beladenta Amalia, Olena Tigova, María José López, Xavier Continente, Teresa Arechávala, Silvano Gallus, Alessandra Lugo, Xiaoqiu Liu, Cristina Bosetti, Enrico Davoli, Istituto Doxa, Paolo Colombo, Sean Semple, Rachel O’Donnell, Ruaraidh Dobson, Luke Clancy, Sheila Keogan, Shashsa Li, Elizabeth Breslin, Panagiotis Behrakis, Anna Tzortzi, Constantine Vardavas, Vergina Konstantina Vyzikidou, Stephanie Teloniatis, Gerasimos Bakelas, George Matiampa, Giuseppe Gorini, Giulia Carreras, Barbara Cortini, Elisabetta Chellini, Roberto Boffi, Ario Ruprecht, Cinzia De Marco, Alessandro Borgini, Chiara Veronese, Martina Bertoldi, Andrea Tittarelli, Ángel López Nicolás, Marta Trapero-Bertrán, Daniel Celdrán Guerrero, Cornel Radu-Loghin, Dominick Nguyen, Polina Starchenko, oan B Soriano, Julio Ancochea, Tamara Alonso, María Teresa Mira-Perceval Pastor, Marta Erro, Ana Pilar Nso‐Roca,

Noise Effects and Management

The current study examined symptoms of irritation reported by non-smokers passively exposed to e-cigarette aerosols and their timing and association with the concentrations of volatile organic compounds (VOCs) produced. 40 healthy non-smoking adults were exposed to e-cigarette aerosols for 30 min in a 35 m3 room. Second-hand e-cigarette aerosol (SHA) was produced by an experienced e-cigarette user using a standardized topography and two resistance settings (exposure 0.5 Ohm and 1.5 Ohm), in addition to a control session (no emissions). PM2.5 and PM1.0 were continuously measured over the duration of exposure, while Volatile Organic Compounds (VOCs) were recorded at 0, 15 and 30 min (t0, t15 and t30) of exposure. Each participant completed an irritation questionnaire at t0, t15, t30 of exposure and t60 (30 min post-exposure) on ocular, nasal, throat-respiratory symptoms of irritation and general complaints. Kruskal-Wallis H test for PM comparisons, repeated measures ANOVA for VOCs and Generalized Estimating Equations for symptoms of irritation and association with VOCs were used for statistical analysis. 20 males and 20 females, with a mean age of 24.6 years (SD = 4.3) and exhaled CO < 7 ppm participated. PM concentrations in both experimental sessions were higher than the Control (p < 0.001). The most commonly reported symptoms were burning, dryness, sore throat, cough, breathlessness and headache. During both experimental sessions, ocular, nasal, throat-respiratory symptoms and general complaints increased significantly (p < 0.05). Ocular and nasal symptoms returned to baseline by t60 (p > 0.05) while throat-respiratory symptoms were still significantly higher at t60 (p = 0.044). VOCs were significantly associated with reported nasal and throat-respiratory symptoms in both experimental sessions (p < 0.05). A 30-min exposure to SHA provoked symptoms of sensory irritation and general complaints that lasted up to 30 min after the exposure and were positively associated with the concentrations of the VOC mixture emitted.