
Tramadol for management of fibromyalgia pain and symptoms: Systematic review
2019; Wiley; Volume: 74; Issue: 3 Linguagem: Inglês
10.1111/ijcp.13455
ISSN1742-1241
AutoresAline Pereira da Rocha, Carolina Christianini Mizzaci, Ana Carolina Pereira Nunes Pinto, Aléxia Gabriela da Silva Vieira, Vinicius Tassoni Civile, Virgínia Fernandes Moça Trevisani,
Tópico(s)Pain Management and Placebo Effect
ResumoInternational Journal of Clinical PracticeVolume 74, Issue 3 e13455 SYSTEMATIC REVIEW Tramadol for management of fibromyalgia pain and symptoms: Systematic review Aline Pereira da Rocha, Corresponding Author Aline Pereira da Rocha alineprocha1@gmail.com orcid.org/0000-0002-0863-6500 Discipline of Evidence-Based Health, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (Unifesp), São Paulo, Brazil Cochrane Brazil, São Paulo, Brazil Correspondence Aline Pereira da Rocha, Evidence Based Health Program, Escola Paulista de Medicina (EPM), Univeridade Federal de São Paulo, Rua Botucatu, São Paulo, Brazil. Email: alineprocha1@gmail.comSearch for more papers by this authorCarolina Christianini Mizzaci, Carolina Christianini Mizzaci orcid.org/0000-0001-7325-1570 Discipline of Evidence-Based Health, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (Unifesp), São Paulo, Brazil Cochrane Brazil, São Paulo, BrazilSearch for more papers by this authorAna Carolina Pereira Nunes Pinto, Ana Carolina Pereira Nunes Pinto orcid.org/0000-0002-1505-877X Discipline of Evidence-Based Health, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (Unifesp), São Paulo, Brazil Cochrane Brazil, São Paulo, Brazil Department of Biological and Health Sciences, Federal University of Para, Belém, Pará, Brazil University of Pittsburgh, Pittsburgh, Pennsylvania, USASearch for more papers by this authorAlexia Gabriela da Silva Vieira, Alexia Gabriela da Silva Vieira orcid.org/0000-0002-6048-716X Discipline of Evidence-Based Health, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (Unifesp), São Paulo, Brazil Cochrane Brazil, São Paulo, BrazilSearch for more papers by this authorVinicius Civile, Vinicius Civile orcid.org/0000-0002-1718-6281 Discipline of Evidence-Based Health, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (Unifesp), São Paulo, Brazil Cochrane Brazil, São Paulo, BrazilSearch for more papers by this authorVirgínia Fernandes Moça Trevisani, Virgínia Fernandes Moça Trevisani orcid.org/0000-0002-7180-6285 Discipline of Evidence-Based Health, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (Unifesp), São Paulo, Brazil Cochrane Brazil, São Paulo, BrazilSearch for more papers by this author Aline Pereira da Rocha, Corresponding Author Aline Pereira da Rocha alineprocha1@gmail.com orcid.org/0000-0002-0863-6500 Discipline of Evidence-Based Health, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (Unifesp), São Paulo, Brazil Cochrane Brazil, São Paulo, Brazil Correspondence Aline Pereira da Rocha, Evidence Based Health Program, Escola Paulista de Medicina (EPM), Univeridade Federal de São Paulo, Rua Botucatu, São Paulo, Brazil. Email: alineprocha1@gmail.comSearch for more papers by this authorCarolina Christianini Mizzaci, Carolina Christianini Mizzaci orcid.org/0000-0001-7325-1570 Discipline of Evidence-Based Health, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (Unifesp), São Paulo, Brazil Cochrane Brazil, São Paulo, BrazilSearch for more papers by this authorAna Carolina Pereira Nunes Pinto, Ana Carolina Pereira Nunes Pinto orcid.org/0000-0002-1505-877X Discipline of Evidence-Based Health, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (Unifesp), São Paulo, Brazil Cochrane Brazil, São Paulo, Brazil Department of Biological and Health Sciences, Federal University of Para, Belém, Pará, Brazil University of Pittsburgh, Pittsburgh, Pennsylvania, USASearch for more papers by this authorAlexia Gabriela da Silva Vieira, Alexia Gabriela da Silva Vieira orcid.org/0000-0002-6048-716X Discipline of Evidence-Based Health, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (Unifesp), São Paulo, Brazil Cochrane Brazil, São Paulo, BrazilSearch for more papers by this authorVinicius Civile, Vinicius Civile orcid.org/0000-0002-1718-6281 Discipline of Evidence-Based Health, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (Unifesp), São Paulo, Brazil Cochrane Brazil, São Paulo, BrazilSearch for more papers by this authorVirgínia Fernandes Moça Trevisani, Virgínia Fernandes Moça Trevisani orcid.org/0000-0002-7180-6285 Discipline of Evidence-Based Health, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (Unifesp), São Paulo, Brazil Cochrane Brazil, São Paulo, BrazilSearch for more papers by this author First published: 04 December 2019 https://doi.org/10.1111/ijcp.13455Citations: 12 Ana Carolina Nunes Pinto: Fullbright Student. Funding information This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brasil (CAPES)- Finance Code 001. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Summary Background Fibromyalgia is a heterogeneous condition that appears to be associated with physiological and biochemical disturbances of pain modulation, and that consequently affects numerous other facets of life. Tramadol is currently being explored as an option to manage fibromyalgia pain and other symptoms because of its inhibitory activity of reuptake of neurotransmitters, but its safety and efficacy have not yet been established in these patients. Objective To evaluate the effectiveness and safety of tramadol on the management of symptoms of the syndrome. Methods We searched CENTRAL, MEDLINE, EMBASE, LILACS, Opengrey, ClinicalTrials.gov and WHO-ICTRP for randomised controlled trials analysing the association between tramadol used for fibromyalgia either single-agent or in combination with other drugs. Two reviewers independently extracted data and assessed risk of bias using the Cochrane risk-of-bias tool for all included studies. Quality of the evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE). Results Four RCTs comprising 459 patients were included. Tramadol—either as a single-agent or in combination with an antidepressant or analgesic—had a positive effect on pain. Tramadol combined with analgesic showed improved quality of life over placebo as measured by the Fibromyalgia Impact Questionnaire at 91 days. However, this difference did not hold for tramadol as a single agent against placebo. The evidence in these articles was rated “low” using the GRADE approach. No serious adverse events were reported. No improvement in depression and quality of sleep were observed. Conclusions This systematic review found a dearth of clinical trials on tramadol in patients with fibromyalgia. Although the combination of monoamine and opioid mechanism of tramadol has shown positive effects for fibromyalgia, the available evidence is not sufficient to support or refute the use of tramadol in clinical practice for pain or symptom management. Protocol registration number in the PROSPERO database: CRD42017062139. DISCLOSURE None. Citing Literature Supporting Information Filename Description ijcp13455-sup-0001-Supinfo.docxWord document, 32.3 KB Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume74, Issue3March 2020e13455 RelatedInformation
Referência(s)