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Longitudinal optic neuritis-unrelated visual evoked potential changes in NMO spectrum disorders

2019; Lippincott Williams & Wilkins; Volume: 94; Issue: 4 Linguagem: Inglês

10.1212/wnl.0000000000008684

1526-632X

Marius Ringelstein, Jens Harmel, Hanna Zimmermann, Alexander U. Brandt, Friedemann Paul, Axel Haarmann, Mathias Buttmann, Martin W. Hümmert, Corinna Trebst, Christoph Schroeder, Ilya Ayzenberg, Ingo Kleiter, Kerstin Hellwig, Joachim Havla, Tania Kümpfel, Sven Jarius, Brigitte Wildemann, Paulus Rommer, Martin S. Weber, Hannah Pellkofer, Luise Röpke, Christian Geis, Nele Retzlaff, Uwe K. Zettl, Michael Deppe, Luisa Klotz, Kim Lea Young, Jan‐Patrick Stellmann, Matthias Kaste, Pawel Kermer, Wael Marouf, Florian Lauda, Hayrettin Tumani, Jonas Graf, Alexander Klistorner, Hans‐Peter Hartung, Orhan Aktaş, Philipp Albrecht, Klemens Angstwurm, Antonios Bayas, Achim Berthele, Judith Bellmann‐Strobl, Felix Bischof, Stefan Bittner, Tobias Böttcher, Johannes Brettschneider, Marcus D’Souza, Barbara Ettrich, Jürgen Faiss, Benedikt Frank, Anna Gahlen, Achim Gass, Matthias Grothe, Kerstin Guthke, Eva Marie Habedank, Bernhard Hemmer, Frank Hoffmann, Olaf Hoffmann, Ulrich Hofstadt‐van Oy, Jutta Junghans, Barbara Kaulen, Peter Kern, Christoph Kleinschnitz, Wolfgang Köhler, Melanie Korsen, Markus C. Kowarik, Markus Krumbholz, Stefan Langel, Martin Liebetrau, Ralf A. Linker, De-Hyung Lee, Felix Luessi, Martin Marziniak, Christoph Mayer, Stefanie Meister, Arthur Melms, Imke Metz, Christoph Münch, Oliver Neuhaus, Sabine Niehaus, Florence Pache, Marc Pawlitzki, Hans-Ulrich Puhlmann, Refik Pul, Kevin Rostásy, Lioba Rückriem, Klemens Ruprecht, Christoph Ruschil, Sven Schippling, S. Schuster, Matthias Schwab, Makbule Şenel, Jörn Peter Sieb, Nadja Siebert, Claudia Sommer, Annette Spreer, Martin Stangel, A. Steinbrecher, Heike Stephanik, Muriel Stoppe, Marie Süße, Björn Tackenberg, Florian Then-Bergh, Johannes Tünnerhoff, Christian Veauthier, Annette O. Walter, Klaus‐Peter Wandinger, Clemens Warnke, Martin S. Weber, Robert Weissert, Heinz Wiendl, Christian Wilke, Alexander Winkelmann, Yavor Yalachkov, Lena Zeltner, Christian Zentner, Ulf Ziemann, Frauke Zipp,

Glaucoma and retinal disorders

To investigate if patients with neuromyelitis optica spectrum disorder (NMOSD) develop subclinical visual pathway impairment independent of acute attacks.A total of 548 longitudinally assessed full-field visual evoked potentials (VEP) of 167 patients with NMOSD from 16 centers were retrospectively evaluated for changes of P100 latencies and P100-N140 amplitudes. Rates of change in latencies (RCL) and amplitudes (RCA) over time were analyzed for each individual eye using linear regression and compared using generalized estimating equation models.The rates of change in the absence of optic neuritis (ON) for minimal VEP intervals of ≥3 months between baseline and last follow-up were +1.951 ms/y (n = 101 eyes; SD = 6.274; p = 0.012) for the P100 latencies and -2.149 µV/y (n = 64 eyes; SD = 5.013; p = 0.005) for the P100-N140 amplitudes. For minimal VEP intervals of ≥12 months, the RCL was +1.768 ms/y (n = 59 eyes; SD = 4.558; p = 0.024) and the RCA was -0.527 µV/y (n = 44 eyes; SD = 2.123; p = 0.111). The history of a previous ON >6 months before baseline VEP had no influence on RCL and RCA. ONs during the observational period led to mean RCL and RCA of +11.689 ms/y (n = 16 eyes; SD = 17.593; p = 0.003) and -1.238 µV/y (n = 11 eyes; SD = 3.708; p = 0.308), respectively.This first longitudinal VEP study of patients with NMOSD provides evidence of progressive VEP latency delay occurring independently of acute ON. Prospective longitudinal studies are needed to corroborate these findings and help to interpret the clinical relevance.