Click Chemistry: Evolving on the Fringe
2019; Wiley; Volume: 38; Issue: 4 Linguagem: Inglês
10.1002/cjoc.201900421
ISSN1614-7065
Autores Tópico(s)Advanced Biosensing Techniques and Applications
ResumoSummary The article herein briefly introduces the story of the birth of click chemistry and its evolution after that. A new angle to interpret click reactions was proposed using the “reactivity‐availability‐functionality” trilogy. CuAAC (Copper‐catalyzed azide‐alkyne cycloaddition), the most popular click reaction by far, was revisited along with the thiol‐ene, metal‐free AAC, SuFEx (Sulfur(VI) fluoride exchange) and the lately discovered diazotransfer process. By encountering more and more near‐perfect reactions, click chemistry is evolving and expanding on the fringe of the chemistry and different scientific disciplines, destination unknown.
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