Portal de Periódicos da CAPES

BISPHOSPHONATE-INDUCED OSTEONECROSIS OF THE JAW: A MAJOR DILEMMA IN OUR CLINICAL ROUTINE

2019; Elsevier BV; Volume: 129; Issue: 1 Linguagem: Inglês

10.1016/j.oooo.2019.06.437

2212-4411

Pâmella de Pinho Montovani, CAMILA BEVILACQUA GUIMARÃES DE ALMEIDA, ALEXANDRE DA ROCHA CURVELO, Ana Clara Elbert, Rogério Jardim Caldas, BRENDA XAVIER DOS SANTOS, MARIA ELISA RANGEL JANINI,

Oral health in cancer treatment

Bisphosphonate-induced osteonecrosis of the jaw is a severe and current effect of long-term use of this drug. Two case reports aim to alert health professionals about the severity and possibility of this pathology. Case 1 was that of an 80-year-old female patient using bisphosphonate who presented 2 mandibular bone spicules that were treated by antibiotic therapy. There was a recurrence of the condition in 6 months, when computed tomography identified bone sequestration that was removed under antibiotic therapy. Case 2 was that of a 70-year-old male patient under chemotherapy and use of bisphosphonate who presented bone sequestration with pus and pain after tooth extraction culminating in pathologic fracture. The patient was referred, and despite his condition, the surgical proposal was the removal of the entire area and placement of fixation plates. The reports demonstrate that the professional team and knowledge are extremely relevant and directly related factors of osteonecrosis of the jaw morbidity. Bisphosphonate-induced osteonecrosis of the jaw is a severe and current effect of long-term use of this drug. Two case reports aim to alert health professionals about the severity and possibility of this pathology. Case 1 was that of an 80-year-old female patient using bisphosphonate who presented 2 mandibular bone spicules that were treated by antibiotic therapy. There was a recurrence of the condition in 6 months, when computed tomography identified bone sequestration that was removed under antibiotic therapy. Case 2 was that of a 70-year-old male patient under chemotherapy and use of bisphosphonate who presented bone sequestration with pus and pain after tooth extraction culminating in pathologic fracture. The patient was referred, and despite his condition, the surgical proposal was the removal of the entire area and placement of fixation plates. The reports demonstrate that the professional team and knowledge are extremely relevant and directly related factors of osteonecrosis of the jaw morbidity.