Produção Nacional
Revisado por pares
In utero and lactational exposure to triclocarban: reproductive effects on female rat offspring
2019; Wiley; Volume: 40; Issue: 4 Linguagem: Inglês
10.1002/jat.3922
ISSN1099-1263
AutoresNathália Orlandini Costa, Lorena Ireno Borges, Liara Freitas Cavalcanti, Bruno Garcia Montagnini, Janete Aparecida Anselmo Franci, Ana Carolina Inhasz Kiss, Daniela Cristina Ceccatto Gerardin,
Tópico(s)Pharmaceutical and Antibiotic Environmental Impacts
ResumoAbstract Triclocarban (TCC) is an antimicrobial compound widely used in personal care products such as soaps, toothpaste, and shampoo. This agent is incompletely removed by wastewater treatment and represents an environmental contaminant. Recent studies have shown that TCC is associated with some endocrine disruptions. The aim of the present study was to evaluate if TCC exposure during critical periods of development (gestation and lactation) could lead to adverse effects on reproductive and behavior parameters of female offspring. Pregnant female Wistar rats were divided into four groups ( n = 8–11/group): Control; TCC 0.3 mg/kg (TCC 0.3); TCC 1.5 mg/kg; TCC 3.0 mg/kg (TCC 3.0); and treated daily by oral gavage from gestational day 0 to lactational day 21. The female pups (F1 generation) were weaned on post‐natal day 21 and included in the study. No litter‐mates were used for the same group. There was a decrease in estradiol levels in the TCC 0.3 and TCC 3.0 groups. Moreover, there was a decrease in progesterone levels and an increase in pre‐implantation loss in the TCC 3.0 group in adulthood. It is suggested, in this study, that the decrease in progesterone biosynthesis could interfere with implantation process. The exposure window to TCC is an important factor, as we found alterations only in the offspring.
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