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Biotechnological potential and applications of microbial consortia

2019; Elsevier BV; Volume: 40; Linguagem: Inglês

10.1016/j.biotechadv.2019.107500

1873-1899

Xiujuan Qian, Lin Chen, Yuan Sui, Chong Chen, Wenming Zhang, Jie Zhou, Weiliang Dong, Min Jiang, Fengxue Xin, Katrin Ochsenreither,

Algal biology and biofuel production

Recent advances in microbial consortia present a valuable approach for expanding the scope of metabolic engineering. Systems biology enable thorough understanding of diverse physiological processes of cells and their interactions, which in turn offers insights into the optimal design of synthetic microbial consortia. Yet, the study of synthetic microbial consortia is still in early infancy, facing many unknowns and challenges in intercellular communication and construction of stable and controllable microbial consortia systems. In this review, we comprehensively discussed the recent application of defined microbial consortia in the fields of human health monitoring and medicine exploitation, valuable compounds synthesis, consolidated bioprocessing of lignocellulosic materials and environmental bioremediation. Moreover, the outstanding challenges and future directions to advance the development of high-efficient, stable and controllable synthetic microbial consortia were highlighted.