Acid‐Cleavable Poly(ethylene glycol) Hydrogels Displaying Protein Release at pH 5
2019; Wiley; Volume: 26; Issue: 13 Linguagem: Inglês
10.1002/chem.201905310
ISSN1521-3765
AutoresEwald Johannes, Jan Blankenburg, Matthias Worm, Laura Besch, Ronald E. Unger, Wolfgang Tremel, Holger Frey, Hannah Pohlit,
Tópico(s)Polymer Surface Interaction Studies
ResumoPEG is the gold standard polymer for pharmaceutical applications, however it lacks degradability. Degradation under physiologically relevant pH as present in endolysosomes, cancerous and inflammatory tissues is crucial for many areas. The authors present anionic ring-opening copolymerization of ethylene oxide with 3,4-epoxy-1-butene (EPB) and subsequent modification to introduce acid-degradable vinyl ether groups as well as methacrylate (MA) units, enabling radical cross-linking. Copolymers with different molar ratios of EPB, molecular weights (M
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