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BIBTEX RIS

cGMP signaling pathway in hepatic encephalopathy neuroinflammation and cognition

2019; Elsevier BV; Volume: 79; Linguagem: Inglês

10.1016/j.intimp.2019.106082

1878-1705

Maria Eduarda Rocha de França, Christina Alves Peixoto,

Pharmacological Effects and Toxicity Studies

Hepatic encephalopathy (HE) is a complex neuropsychiatric syndrome that results from liver failure and is characterized by a wide range of symptoms such as alteration in the sleep-waking cycle, neuromuscular coordination, mood, and cognition. The deregulation of nitric oxide (NO)/cyclic guanosine monophosphate (cGMP)/protein kinase G (PKG) signaling pathway is thought to play an important role in the etiology and progression of neurodegenerative diseases, and several studies pointed that the cGMP signaling is impaired in patients with HE and experimental models of chronic hyperammonemia. This review aimed to briefly present the current knowledge of the cGMP signaling pathways in neuroinflammation, neurogenesis, and memory in hepatic encephalopathy and its potential therapeutic role.