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A cohort study to assess the incidence of dengue, Brazil, 2014–2018

2019; Elsevier BV; Volume: 204; Linguagem: Inglês

10.1016/j.actatropica.2019.105313

1873-6254

Expedito José de Albuquerque Luna, Gerusa Maria Figueiredo, José Eduardo Levi, Sérgio Roberto de Souza Leão da Costa Campos, Alvina Clara Félix, Nathalia Santiago e Souza, Walter Manso Figueiredo, Ângela Costa, Maria Regina Alves Cardoso, Cláudio Mendes Pannuti,

Zoonotic diseases and public health

The present cohort study was set up with the aim of determining the incidence of dengue among children and adolescents, from 2 to 16 years of age, living in Araraquara, South-Eastern Brazil, a city classified as a mid-level endemicity location for dengue. Enrollment took place from September 2014 to March 2015. Baseline socio-demographic data were collected, and a blood sample from the participant was drawn, for dengue serology. Families were contacted weekly for fever surveillance. If the child developed fever, a nurse visited the household to collect a blood sample. PCR, NS1 and IgM were used for dengue diagnosis. Parents or legal guardians of participating children provided a written informed consent. 3,514 children and adolescents were enrolled in the cohort. Dengue baseline seroprevalence was 12.2% (95%CI: 11.1 - 13.3). The incidence density of symptomatic dengue was 8.94 per 100 person/years in the first year of follow-up, 0.58 in the second, and 0.19 in the fourth. No cases were confirmed in the third year. Incidence was associated with age, sex, baseline seroprevalence and with living in a house as opposed to an apartment. This study provides relevant information on the epidemiology of dengue in mid-level transmission settings that may be useful to policymakers in the evaluation of control strategies.