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Early neonatal outcomes of very-low-birth-weight infants in Turkey: A prospective multicenter study of the Turkish Neonatal Society

2019; Public Library of Science; Volume: 14; Issue: 12 Linguagem: Inglês

10.1371/journal.pone.0226679

1932-6203

Esin Koç, Nihal Demirel, Ahmet Yağmur Baş, Dilek Ulubaş Işık, İbrahim Murat Hirfanoğlu, Turan Tunç, Fatma Nur Sarı, Güner Karatekın, Рамазан Оздемир, Hüseyin Altunhan, Merih Çetınkaya, Beyza Özcan, Servet Özkiraz, Şebnem Çalkavur, Kadir Şerafettin Tekgündüz, Ayhan Taştekın, Ferda Özlü, Banu Mutlu Özyurt, Ahmet Özdemir, Bilin Çetinkaya, Yaşar Demirelli, Esad Köklü, Ülker Çelik, Nuriye Tarakçı, Didem Armangil, Emel Okulu, Fatma Narter, Birgül Mutlu, Mustafa Kurthan Mert, Ali Bülbül, Hüseyin Selim Asker, Özgün Uygur, İlker Uslu, Sabahattin Ertuğrul, Cumhur Aydemir, Hasan Tolga Çelik, Kazım Küçüktaşçi, Selda Arslan, Hacer Ergin, Ayşegül Zenciroğlu, Sadık Yurttutan, Ayşen Orman, Oğuz Tuncer, Beril Yaşa, Betül Acunaş, Şahin Takçı, Zeynel Gökmen, Hilal Özkan, Serdar Cömert, Nuran Üstün, Mehmet Mutlu, Bilge Tanyeri Bayraktar, Leyla Bilgin, Funda Tüzün, Özge Aydemir, Tuğba Gürsoy, Arzu Akdağ, Aslı Memişoğlu, Emrah Can, Demet Terek, Serdar Beken, Özden Turan, Nilüfer Güzoğlu, Rahmi Örs, Yusuf Kale, Berna Hekimoğlu, Hakan Aylanç, Funda Eroglu, Suzan Şahin, Murat Konak, Dilek Sarıcı, İlknur Kılıç, Nilay Hakan,

Congenital Heart Disease Studies

Objective To investigate the early neonatal outcomes of very-low-birth-weight (VLBW) infants discharged home from neonatal intensive care units (NICUs) in Turkey. Material and methods A prospective cohort study was performed between April 1, 2016 and April 30, 2017. The study included VLBW infants admitted to level III NICUs. Perinatal and neonatal data of all infants born with a birth weight of ≤1500 g were collected for infants who survived. Results Data from 69 NICUs were obtained. The mean birth weight and gestational age were 1137±245 g and 29±2.4 weeks, respectively. During the study period, 78% of VLBW infants survived to discharge and 48% of survived infants had no major neonatal morbidity. VLBW infants who survived were evaluated in terms of major morbidities: bronchopulmonary dysplasia was detected in 23.7% of infants, necrotizing enterocolitis in 9.1%, blood culture proven late-onset sepsis (LOS) in 21.1%, blood culture negative LOS in 21.3%, severe intraventricular hemorrhage in 5.4% and severe retinopathy of prematurity in 11.1%. Hemodynamically significant patent ductus arteriosus was diagnosed in 24.8% of infants. Antenatal steroids were administered to 42.9% of mothers. Conclusion The present investigation is the first multicenter study to include epidemiological information on VLBW infants in Turkey. Morbidity rate in VLBW infants is a serious concern and higher than those in developed countries. Implementation of oxygen therapy with appropriate monitoring, better antenatal and neonatal care and control of sepsis may reduce the prevalence of neonatal morbidities. Therefore, monitoring standards of neonatal care and implementing quality improvement projects across the country are essential for improving neonatal outcomes in Turkish NICUs.