Portal de Periódicos da CAPES

Tuning the allosteric sequestration of anticancer drugs for developing cooperative nano-antidotes

2019; Royal Society of Chemistry; Volume: 56; Issue: 8 Linguagem: Inglês

10.1039/c9cc09373g

1364-548X

Wei‐Kun Wang, Tyler J. Finnegan, Zhi‐Quan Lei, Xingrong Zhu, Curtis E. Moore, Kejia Shi, Jovica D. Badjić,

Innovative Microfluidic and Catalytic Techniques Innovation

A dual-cavity basket 16-, holding six γ-aminobutyric acids at its termini, encapsulates variously sized aromatics 2-7+, including four anthracyclines (8+-11+), driven by the hydrophobic effect and hydrogen bonding (HB). In particular, the formation of stable (K = 1012 M-2) anthracycline complexes [(8+-11+)2⊂16-], assembled into nanoparticles, occurred with positive homotropic cooperativity (α = 4K2/K1 = 1.1 ± 0.3 × 102-1.3 ± 0.7 × 103) in PBS medium. Importantly, weakening the first binding event (K1, i.e. by removing HBs) turned the second one (K2) more favorable. The finding is of interest for developing cooperative nano-antidotes acting as biodetoxifying agents.