A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1
2019; American Association for the Advancement of Science; Volume: 366; Issue: 6472 Linguagem: Inglês
10.1126/science.aav3900
ISSN1095-9203
AutoresJérôme Le Nours, Nicholas A. Gherardin, Sri H. Ramarathinam, Wael Awad, Florian Wiede, Benjamin S. Gully, Yogesh Khandokar, T. Praveena, Jacinta M. Wubben, Jarrod J. Sandow, Andrew I. Webb, Anouk von Borstel, Michael T. Rice, Samuel J. Redmond, Rebecca Seneviratna, Maria L. Sandoval-Romero, Shihan Li, Michael N. T. Souter, Sidonia B. G. Eckle, Alexandra J. Corbett, Hugh H. Reid, Ligong Liu, David P. Fairlie, Edward Giles, Glen P. Westall, Richard W. Tothill, Martin S. Davey, Richard Berry, Tony Tiganis, James McCluskey, Daniel G. Pellicci, Anthony W. Purcell, Adam P. Uldrich, Dale I. Godfrey, Jamie Rossjohn,
Tópico(s)Cytomegalovirus and herpesvirus research
ResumoA different way for γδ T cells to bind The ligands bound by γδ T cell receptors (TCRs) are less well characterized than those of their αβ TCR cousins, which are antigens presented by major histocompatibility complex (MHC) and related proteins. Le Nours et al. identified a phenotypically diverse γδ T cell subset in human tissues that reacts to MHC-related protein 1 (MR1), which presents vitamin B derivatives. A crystal structure of a γδ TCR–MR1–antigen complex revealed that some of these TCRs can bind underneath the MR1 antigen-binding cleft instead of recognizing the presented antigen. This work thus uncovers an additional ligand for γδ T cells and reconceptualizes the nature of T cell antigen recognition. Science , this issue p. 1522
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