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Synthesis and Characterization of New Multifunctional Self-Boosted Filters for UV Protection: ZnO Complex with Dihydroxyphenyl Benzimidazole Carboxylic Acid

2019; Multidisciplinary Digital Publishing Institute; Volume: 24; Issue: 24 Linguagem: Inglês

10.3390/molecules24244546

1433-1373

Mattia Battistin, Elisa Durini, Valeria Dissette, Alessandro Bonetto, Antonio Marcomini, Elisa Casagrande, Andrea Brunetta, Paola Ziosi, Sonia Molesini, Riccardo Gavioli, Francesco Nicoli, Stefano Manfredini, Silvia Vertuani, Anna Baldisserotto,

Photodynamic Therapy Research Studies

The incidence of skin cancer is increasing both because of climate change and the increase in pollution than people's incorrect habits of sun exposure. In these regards, sunscreen and photoprotection are essential tools in consenting the benefits induced by safe solar light exposition and skin cancer prevention. In this work, a new class of sunscreen filter was synthesized by chemical combination of a physical filter (ZnO) and Oxisol (dihydroxyphenyl benzimidazole carboxylic acid), an antioxidant molecule with booster effect. In this work, a new class of filters with new properties was achieved by direct functionalization of particles surface. A full characterization of this multifunctional ingredient (ZnO-Ox) was conducted: Compared with the simple mixture, the new filter acts as a multifunctional molecule showing a higher Sun Protection Factor (SPF), a better cytotoxic profile (MTT and NRU assay), and anti-acne activity. A strong reduction of photocatalytic activity of ZnO was observed, also improving the safety profile.