Discovery, biosynthesis and antifungal mechanism of the polyene-polyol meijiemycin
2019; Royal Society of Chemistry; Volume: 56; Issue: 5 Linguagem: Inglês
10.1039/c9cc08908j
ISSN1364-548X
AutoresZhen Jie Low, Juan Xiong, Ying Xie, Guang‐Lei Ma, Howard Saw, Hòa Thị Trần, Soo Lin Wong, Li Pang, July Fong, Peng Lu, Jin‐Feng Hu, Liang Yang, Yansong Miao, Zhao‐Xun Liang,
Tópico(s)Polysaccharides and Plant Cell Walls
ResumoProduced by a newly isolated Streptomycetes strain, meijiemycin is a gigantic linear polyene-polyol that exhibits structural features not seen in other members of the polyene-polyol family. We propose a biosynthetic mechanism and demonstrate that meijiemycin inhibits hyphal growth by inducing the aggregation of ergosterol and restructuring of the fungal plasma membrane.
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